Abstract：
BACKGROUND: The increasing quest for effective and safe antiaging skincare solutions has led to a surge in the exploration of natural compounds such as phenolic acids. Despite the proven efficacy of traditional antiaging ingredients like retinol, their associated side effects have necessitated the search for alternatives.
OBJECTIVE: This study aimed to assess the anti-wrinkle efficacy of a standardized phenolic acids polymer extract (PAPE) from propolis, employing both in vitro and clinical methodologies to explore its suitability as a novel antiaging skincare ingredient for sensitive and nonsensitive skin types.
METHODS: The study comprised of evaluating PAPE effects on key skin health biomarkers in dermal fibroblasts and keratinocytes. A double-blind, randomized clinical trial involving female participants aged 30-70 years assessed the wrinkle-reducing effectiveness of face creams formulated with two concentrations of PAPE (1.5% and 3%) over a 28-day period.
RESULTS: In vitro studies indicated that PAPE could modulate inflammation and tissue remodeling biomarkers. The clinical trial demonstrated that applying PAPE-enriched cream resulted in significant wrinkle reduction, with 25% and 34% improvements for the 1.5% and 3% PAPE formulations, respectively. Subjective feedback from participants further validated the antiaging efficacy and overall satisfaction with the product.
CONCLUSIONS: Incorporating PAPE offers a compelling antiaging solution, significantly reducing wrinkle depth with a favorable safety profile. The study substantiates PAPE\'s potential as an effective and safe alternative to conventional antiaging ingredients, aligning with the cosmetic industry\'s shift toward natural, evidence-based formulations.
OBJECTIVE: This study aimed to assess the anti-wrinkle efficacy of a standardized phenolic acids polymer extract (PAPE) from propolis, employing both in vitro and clinical methodologies to explore its suitability as a novel antiaging skincare ingredient for sensitive and nonsensitive skin types.
METHODS: The study comprised of evaluating PAPE effects on key skin health biomarkers in dermal fibroblasts and keratinocytes. A double-blind, randomized clinical trial involving female participants aged 30-70 years assessed the wrinkle-reducing effectiveness of face creams formulated with two concentrations of PAPE (1.5% and 3%) over a 28-day period.
RESULTS: In vitro studies indicated that PAPE could modulate inflammation and tissue remodeling biomarkers. The clinical trial demonstrated that applying PAPE-enriched cream resulted in significant wrinkle reduction, with 25% and 34% improvements for the 1.5% and 3% PAPE formulations, respectively. Subjective feedback from participants further validated the antiaging efficacy and overall satisfaction with the product.
CONCLUSIONS: Incorporating PAPE offers a compelling antiaging solution, significantly reducing wrinkle depth with a favorable safety profile. The study substantiates PAPE\'s potential as an effective and safe alternative to conventional antiaging ingredients, aligning with the cosmetic industry\'s shift toward natural, evidence-based formulations.
摘要：
背景：对有效和安全的抗衰老护肤解决方案的日益追求导致了对天然化合物如酚酸的探索激增。尽管视黄醇等传统抗衰老成分的功效已得到证实，它们相关的副作用需要寻找替代品。
目的：本研究旨在评估蜂胶的标准化酚酸聚合物提取物（PAPE）的抗皱功效，采用体外和临床方法来探索其作为敏感和非敏感皮肤类型的新型抗衰老护肤成分的适用性。
方法：该研究包括评估PAPE对真皮成纤维细胞和角质形成细胞中关键皮肤健康生物标志物的影响。双盲，纳入30~70岁女性参与者的随机临床试验评估了用两种浓度的PAPE(1.5%和3%)配制的面霜在28天内的除皱效果.
结果：体外研究表明，PAPE可以调节炎症和组织重塑的生物标志物。临床试验表明，应用富含PAPE的乳膏可显著减少皱纹，1.5%和3%PAPE配方有25%和34%的改进，分别。参与者的主观反馈进一步验证了抗衰老功效和对产品的总体满意度。
结论：加入PAPE提供了一个引人注目的抗衰老解决方案，显着减少皱纹深度，具有良好的安全性。该研究证实了PAPE作为常规抗衰老成分的有效和安全替代品的潜力，与化妆品行业向自然的转变保持一致，基于证据的配方。
目的：本研究旨在评估蜂胶的标准化酚酸聚合物提取物（PAPE）的抗皱功效，采用体外和临床方法来探索其作为敏感和非敏感皮肤类型的新型抗衰老护肤成分的适用性。
方法：该研究包括评估PAPE对真皮成纤维细胞和角质形成细胞中关键皮肤健康生物标志物的影响。双盲，纳入30~70岁女性参与者的随机临床试验评估了用两种浓度的PAPE(1.5%和3%)配制的面霜在28天内的除皱效果.
结果：体外研究表明，PAPE可以调节炎症和组织重塑的生物标志物。临床试验表明，应用富含PAPE的乳膏可显著减少皱纹，1.5%和3%PAPE配方有25%和34%的改进，分别。参与者的主观反馈进一步验证了抗衰老功效和对产品的总体满意度。
结论：加入PAPE提供了一个引人注目的抗衰老解决方案，显着减少皱纹深度，具有良好的安全性。该研究证实了PAPE作为常规抗衰老成分的有效和安全替代品的潜力，与化妆品行业向自然的转变保持一致，基于证据的配方。
