Abstract：
Patients with brain tumors suffer from intense psychosocial distress. Although the prevalence of depressive symptoms in patients with brain tumors is high, the pharmacological antidepressant treatment of those patients is not well defined and results from clinical trials are largely missing. In this review, we describe the current standard of evidence and clinical guidelines for the pharmacological treatment of depression in brain tumor patients. We present specific side effects and interactions that should guide treatment decisions. Furthermore, we provide evidence for the diagnosis, screening and risk factors for depression in brain tumor patients and we elaborate on potential antineoplastic effects of antidepressant drugs and ongoing clinical trials. Antidepressant drugs should not be withheld from patients with brain tumors. Future clinical trials should explore the effectiveness and side effects of antidepressants in this specific patient population.
摘要：
脑肿瘤患者遭受强烈的社会心理困扰。虽然脑肿瘤患者抑郁症状的患病率很高,这些患者的药物抗抑郁治疗尚不明确，临床试验结果大部分缺失。在这次审查中,我们描述了目前脑肿瘤患者抑郁症药物治疗的证据标准和临床指南。我们提出了具体的副作用和相互作用，应指导治疗决策。此外，我们为诊断提供证据，筛查和脑肿瘤患者抑郁症的危险因素，我们详细阐述抗抑郁药物的潜在抗肿瘤作用和正在进行的临床试验。脑肿瘤患者不应服用抗抑郁药物。未来的临床试验应该探索抗抑郁药在这一特定患者人群中的有效性和副作用。
