PDF(Pubmed)
Abstract：
BACKGROUND: Spatial normalization to a standardized brain template is a crucial step in magnetic resonance imaging (MRI) studies. Brain templates made from sufficient sample size have low brain variability, improving the accuracy of spatial normalization. Using population-specific template improves accuracy of spatial normalization because brain morphology varies according to ethnicity and age.
METHODS: We constructed a brain template of normal Korean elderly (KNE200) using MRI scans 100 male and 100 female aged over 60 years old with normal cognition. We compared the deformation after spatial normalization of the KNE200 template to that of the KNE96, constructed from 96 cognitively normal elderly Koreans and to that of the brain template (OCF), constructed from 434 non-demented older Caucasians to examine the effect of sample size and ethnicity on the accuracy of brain template, respectively. We spatially normalized the MRI scans of elderly Koreans and quantified the amount of deformations associated with spatial normalization using the magnitude of displacement and volumetric changes of voxels.
RESULTS: The KNE200 yielded significantly less displacement and volumetric change in the parahippocampal gyrus, medial and posterior orbital gyrus, fusiform gyrus, gyrus rectus, cerebellum and vermis than the KNE96. The KNE200 also yielded much less displacement in the cerebellum, vermis, hippocampus, parahippocampal gyrus and thalamus and much less volumetric change in the cerebellum, vermis, hippocampus and parahippocampal gyrus than the OCF.
CONCLUSIONS: KNE200 had the better accuracy than the KNE96 due to the larger sample size and was far accurate than the template constructed from elderly Caucasians in elderly Koreans.
METHODS: We constructed a brain template of normal Korean elderly (KNE200) using MRI scans 100 male and 100 female aged over 60 years old with normal cognition. We compared the deformation after spatial normalization of the KNE200 template to that of the KNE96, constructed from 96 cognitively normal elderly Koreans and to that of the brain template (OCF), constructed from 434 non-demented older Caucasians to examine the effect of sample size and ethnicity on the accuracy of brain template, respectively. We spatially normalized the MRI scans of elderly Koreans and quantified the amount of deformations associated with spatial normalization using the magnitude of displacement and volumetric changes of voxels.
RESULTS: The KNE200 yielded significantly less displacement and volumetric change in the parahippocampal gyrus, medial and posterior orbital gyrus, fusiform gyrus, gyrus rectus, cerebellum and vermis than the KNE96. The KNE200 also yielded much less displacement in the cerebellum, vermis, hippocampus, parahippocampal gyrus and thalamus and much less volumetric change in the cerebellum, vermis, hippocampus and parahippocampal gyrus than the OCF.
CONCLUSIONS: KNE200 had the better accuracy than the KNE96 due to the larger sample size and was far accurate than the template constructed from elderly Caucasians in elderly Koreans.
摘要：
背景：对标准化的大脑模板进行空间归一化是磁共振成像（MRI）研究中的关键步骤。由足够的样本量制成的大脑模板具有较低的大脑变异性，提高空间归一化的精度。使用特定于人群的模板提高了空间归一化的准确性，因为大脑形态根据种族和年龄而变化。
方法：我们使用MRI扫描100名男性和100名女性60岁以上认知正常的韩国老年人（KNE200）构建了一个脑模板。我们将KNE200模板的空间归一化后的变形与由96名认知正常的老年韩国人构建的KNE96的变形进行了比较，并与大脑模板（OCF）的变形进行了比较，由434名非痴呆的老年高加索人构建，以检查样本量和种族对大脑模板准确性的影响，分别。我们对韩国老年人的MRI扫描进行了空间归一化，并使用位移的大小和体素的体积变化来量化与空间归一化相关的变形量。
结果：KNE200在海马旁回产生的位移和体积变化明显减少，眶内侧和后回，梭状回,回直肌,小脑和疣比KNE96。KNE200也减少了小脑的位移，Vermis,海马体,海马旁回和丘脑，小脑的体积变化要小得多，Vermis,海马和海马旁回比OCF。
结论：KNE200具有比KNE96更好的准确性，这是由于样本量更大，并且远比由韩国老年白种人构建的模板准确。
方法：我们使用MRI扫描100名男性和100名女性60岁以上认知正常的韩国老年人（KNE200）构建了一个脑模板。我们将KNE200模板的空间归一化后的变形与由96名认知正常的老年韩国人构建的KNE96的变形进行了比较，并与大脑模板（OCF）的变形进行了比较，由434名非痴呆的老年高加索人构建，以检查样本量和种族对大脑模板准确性的影响，分别。我们对韩国老年人的MRI扫描进行了空间归一化，并使用位移的大小和体素的体积变化来量化与空间归一化相关的变形量。
结果：KNE200在海马旁回产生的位移和体积变化明显减少，眶内侧和后回，梭状回,回直肌,小脑和疣比KNE96。KNE200也减少了小脑的位移，Vermis,海马体,海马旁回和丘脑，小脑的体积变化要小得多，Vermis,海马和海马旁回比OCF。
结论：KNE200具有比KNE96更好的准确性，这是由于样本量更大，并且远比由韩国老年白种人构建的模板准确。
