Abstract：
BACKGROUND: Adult people living with Cystic Fibrosis (CF) undergo annual screening for CF-related diabetes. These tests represent a burden and can lead to undesirable effects resulting in low adherence. The objectives of this study were to 1) compare gold-standard in-hospital oral glucose tolerance testing (OGTT) with at-home options, and 2) evaluate acceptability of at-home options.
METHODS: A total of 34 adults living with CF undertook 3 types of OGTTs in standardized conditions within two weeks: 1) in a hospital using a 75 g glucose beverage, 2) at home with the same glucose beverage, and 3) at home using a standardized quantity of candy. Glucose levels were measured prior to the OGTT, after 1 and 2 hours. Concordance of glucose measurement, side effects and general appreciation were assessed across the three options.
RESULTS: Mean blood glucose was comparable among the three tests. Glucose tolerance categorization (normal, impaired glucose tolerance, or diabetes) was concordant with the hospital reference test in 59 % of participants for the glucose beverage and 75 % for the candies. Side effects were mild with all types of OGTTs, and 94 % of participants preferred the home options. Among the at-home OGTTs, the glucose beverage was preferred to the candy option.
CONCLUSIONS: Home-based OGTT could be an alternative to gold standard hospital-based OGTT testing, improving adherence to annual testing and reducing costs. However, the discrepancy between various OGTT testing methods could lead to diagnosis dilemma. This approach should be tested on a larger sample size.
METHODS: A total of 34 adults living with CF undertook 3 types of OGTTs in standardized conditions within two weeks: 1) in a hospital using a 75 g glucose beverage, 2) at home with the same glucose beverage, and 3) at home using a standardized quantity of candy. Glucose levels were measured prior to the OGTT, after 1 and 2 hours. Concordance of glucose measurement, side effects and general appreciation were assessed across the three options.
RESULTS: Mean blood glucose was comparable among the three tests. Glucose tolerance categorization (normal, impaired glucose tolerance, or diabetes) was concordant with the hospital reference test in 59 % of participants for the glucose beverage and 75 % for the candies. Side effects were mild with all types of OGTTs, and 94 % of participants preferred the home options. Among the at-home OGTTs, the glucose beverage was preferred to the candy option.
CONCLUSIONS: Home-based OGTT could be an alternative to gold standard hospital-based OGTT testing, improving adherence to annual testing and reducing costs. However, the discrepancy between various OGTT testing methods could lead to diagnosis dilemma. This approach should be tested on a larger sample size.
摘要：
背景：患有囊性纤维化（CF）的成年人每年都要接受CF相关糖尿病的筛查。这些测试代表了负担并且可能导致不期望的效果,导致低粘附性。这项研究的目的是1）比较金标准住院口服葡萄糖耐量测试（OGTT）与家庭选择，和2)评估在家选择的可接受性。
方法：共有34名患有CF的成年人在两周内在标准化条件下接受了3种类型的OGTT：1）在医院使用75克葡萄糖饮料，2）在家里用同样的葡萄糖饮料，和3)在家里使用标准化数量的糖果。在OGTT之前测量葡萄糖水平，1和2小时后。葡萄糖测量的一致性，评估了三种选择的副作用和总体评价。
结果：在三个测试中，平均血糖是相当的。葡萄糖耐量分类（正常，糖耐量受损,或糖尿病）在59％的葡萄糖饮料和75％的糖果参与者中与医院参考测试一致。所有类型的OGTT的副作用都很轻微，94%的参与者更喜欢家庭选择。在家庭OGTT中，葡萄糖饮料比糖果更受欢迎。
结论：基于家庭的OGTT可以替代基于医院的黄金标准OGTT测试，提高对年度测试的依从性并降低成本。然而,各种OGTT检测方法之间的差异可能导致诊断困境.这种方法应该在更大的样本量上进行测试。
方法：共有34名患有CF的成年人在两周内在标准化条件下接受了3种类型的OGTT：1）在医院使用75克葡萄糖饮料，2）在家里用同样的葡萄糖饮料，和3)在家里使用标准化数量的糖果。在OGTT之前测量葡萄糖水平，1和2小时后。葡萄糖测量的一致性，评估了三种选择的副作用和总体评价。
结果：在三个测试中，平均血糖是相当的。葡萄糖耐量分类（正常，糖耐量受损,或糖尿病）在59％的葡萄糖饮料和75％的糖果参与者中与医院参考测试一致。所有类型的OGTT的副作用都很轻微，94%的参与者更喜欢家庭选择。在家庭OGTT中，葡萄糖饮料比糖果更受欢迎。
结论：基于家庭的OGTT可以替代基于医院的黄金标准OGTT测试，提高对年度测试的依从性并降低成本。然而,各种OGTT检测方法之间的差异可能导致诊断困境.这种方法应该在更大的样本量上进行测试。
