Abstract：
Two recent seminal works have untangled the intricate role of tumor-associated senescent cells in cancer progression, or regression, by guiding our immune system against cancer cells. The characterization of these unique, yet diverse cell populations, should be considered, particularly when contemplating the use of senolytics, which are drugs that selectively eliminate senescent cells, in a cancer framework. Here, we will describe the current knowledge in this field. In particular, we will discuss how the presence of senescent cells in tumors could be used as a therapeutic target in immunogenic cancers and how we may hypothetically design an adaptive anti-aging vaccine.
摘要：
最近的两项开创性工作揭示了肿瘤相关衰老细胞在癌症进展中的复杂作用，或回归，通过引导我们的免疫系统抵抗癌细胞。这些独特的表征，然而不同的细胞群体，应该考虑,特别是当考虑使用senolyics时，它们是选择性消除衰老细胞的药物，在癌症框架中。这里,我们将描述该领域的当前知识。特别是,我们将讨论肿瘤中衰老细胞的存在如何作为免疫原性癌症的治疗靶点,以及我们如何假设设计适应性抗衰老疫苗.
