Abstract：
Enterococci are Gram-positive coccus bacteria that are normally present in the gastrointestinal tract and ordinarily function commensally with humans. Very few studies have investigated the characteristics of enterococcal infections. We aimed to characterize patients with urinary tract infections (UTIs) due to Enterococci and their outcomes. This was a retrospective cohort study between June 2012-November 2022. Patients who had clinically and microbiologically confirmed Enterococcal UTI based on a urine culture positive for E. faecalis or E. faecium with a count of ≥ 105 CFU/mL and having urinary tract symptoms were included. A total of 396 patients were eligible and included. The patients had a median age of 61 years and were mostly females (56.8%). The most common characteristics were hospitalization in a non-ICU ward, having a urinary catheter, and recent use of antibiotics within the last 3 months (66.4%, 59.3%, and 51.8%, respectively). Infection with E. faecalis was more common than E. faecium (77.3% vs. 22.7%). However, the latter exhibited higher rates of antibiotic resistance (P<0.001 to several antibiotics) and was associated with significantly higher median C-reactive protein level (26.7 vs. 13 mg/dL; P=0.025), mortality (23% vs. 10.1%; P=0.002), and median length of stay (25 vs. 11.5 days; P<0.001). We found that most patients with enterococcal UTIs had a history of having a urinary catheter and recent antibiotic use and were mostly females and hospitalized in non-ICU wards. E. faecium-infected patients experienced more severe episodes and poorer outcomes compared to patients infected with E. faecalis; thus, would need more aggressive therapy.
摘要：
肠球菌是通常存在于胃肠道中并且通常与人类共同起作用的革兰氏阳性球菌细菌。很少有研究调查肠球菌感染的特征。我们旨在描述由于肠球菌引起的尿路感染（UTI）患者及其结局。这是2012年6月至2022年11月之间的回顾性队列研究。包括基于粪肠球菌或屎肠球菌尿培养阳性且计数≥105CFU/mL且有尿路症状的临床和微生物学证实为肠球菌UTI的患者。共有396名患者符合条件并纳入。患者的中位年龄为61岁，大部分为女性（56.8％）。最常见的特征是非ICU病房住院，有导尿管，以及最近3个月内最近使用抗生素(66.4%，59.3%,51.8%，分别)。粪肠球菌感染比粪肠球菌更常见(77.3%vs.22.7%）。然而,后者表现出较高的抗生素耐药率（对几种抗生素P<0.001），并与明显较高的中位数C反应蛋白水平（26.7vs.13mg/dL；P=0.025），死亡率（23%vs.10.1%;P=0.002),和中位住院时间(25vs.11.5天；P<0.001）。我们发现，大多数患有肠球菌性UTI的患者都有导尿管和最近使用抗生素的病史，并且大多数是女性，在非ICU病房住院。与粪肠球菌感染的患者相比，粪肠球菌感染的患者经历了更严重的发作和较差的预后；因此，需要更积极的治疗.
