Abstract：
Inspired by the strong light absorption of carbon nanotubes, we propose a fabrication approach involving one-dimensional TiO2/Bi2S3 QDs nanotubes (TBNTs) with visible red-light excitable photoelectric properties. By integrating the construction of heterojunctions, quantum confinement effects, and morphological modifications, the photocurrent reached 9.22 μA/cm2 which is 66 times greater than that of TiO2 nanotubes (TNTs). Then, a red light-responsive photoelectroactive hydrogel dressing (TBCHA) was developed by embedding TBNTs into a collagen/hyaluronic acid-based biomimetic extracellular matrix hydrogel with good biocompatibility, aiming to promote wound healing and skin function restoration. This approach is primarily grounded in the recognized significance of electrical stimulation in modulating nerve function and immune responses. Severe burns are often accompanied by extensive damage to epithelial-neural networks, leading to a loss of excitatory function and difficulty in spontaneous healing, while conventional dressings inadequately address the critical need for nerve reinnervation. Furthermore, we highlight the remarkable ability of the TBCHA photoelectric hydrogel to promote the reinnervation of nerve endings, facilitate the repair of skin substructures, and modulate immune responses in a deep burn model. This hydrogel not only underpins wound closure and collagen synthesis but also advances vascular reformation, immune modulation, and neural restoration. This photoelectric-based therapy offers a robust solution for the comprehensive repair of deep burns and functional tissue regeneration. STATEMENT OF SIGNIFICANCE: We explore the fabrication of 1D TiO2/Bi2S3 nanotubes with visible red-light excitability and high photoelectric conversion properties. By integrating heterojunctions, quantum absorption effects, and morphological modifications, the photocurrent of TiO2/Bi2S3 nanotubes could reach 9.22 μA/cm², which is 66 times greater than that of TiO2 nanotubes under 625 nm illumination. The efficient red-light excitability solves the problem of poor biosafety and low tissue penetration caused by shortwave excitation. Furthermore, we highlight the remarkable ability of the TiO2/Bi2S3 nanotubes integrated photoelectric hydrogel in promoting the reinnervation of nerve endings and modulating immune responses. This work proposes an emerging therapeutic strategy of remote, passive electrical stimulation, offering a robust boost for repairing deep burn wounds.
摘要：
受碳纳米管强烈光吸收的启发，我们提出了一种制造方法，涉及一维TiO2/Bi2S3QDs纳米管（TBNTs）具有可见红光可激发的光电性能。通过整合异质结的构造，量子限制效应，和形态学修饰，光电流达到9.22μA/cm2,是TiO2纳米管(TNTs)的66倍。然后，通过将红光响应的光电活性水凝胶敷料（TBCHA）将TBNTs嵌入到具有良好生物相容性的基于胶原/透明质酸的仿生细胞外基质水凝胶中，旨在促进伤口愈合和皮肤功能恢复。这种方法主要基于电刺激在调节神经功能和免疫反应中的公认重要性。严重烧伤常伴有上皮神经网络的广泛损伤,导致兴奋功能丧失和难以自发愈合，而常规敷料不足以解决神经神经支配的关键需求。此外，我们强调了TBCHA光电水凝胶促进神经末梢神经支配的非凡能力，促进皮肤亚结构的修复，并调节深度烧伤模型中的免疫反应。这种水凝胶不仅支持伤口闭合和胶原蛋白合成，而且促进血管重建，免疫调节，和神经恢复。这种基于光电的疗法为深度烧伤和功能性组织再生的全面修复提供了强大的解决方案。意义：我们探索了具有可见红光兴奋性和高光电转换性能的1DTiO2/Bi2S3纳米管的制备。通过集成异质结，量子吸收效应，和形态学修饰，TiO2/Bi2S3纳米管的光电流可达9.22μA/cm²，在625nm的光照下，这是TiO2纳米管的66倍。有效的红光兴奋性解决了由短波激发引起的生物安全性差和组织穿透率低的问题。此外，我们强调了TiO2/Bi2S3纳米管集成光电水凝胶在促进神经末梢神经支配和调节免疫反应方面的显着能力。这项工作提出了一种新兴的远程治疗策略，被动电刺激,为修复深度烧伤伤口提供了强大的助力。
