Abstract：
The incidence of colorectal cancer (CRC) in patients under 50 has been increasing over the past several decades. The factors underlying the increase in early onset colorectal cancer (EOCRC) are not entirely clear, although several genetic and clinical differences with late onset colorectal cancer (LOCRC) have been noted. EOCRC cases are often diagnosed at a more advanced stage, raising the possibility that these cancers progress more rapidly than LOCRC cases. The impact of age on cancer progression is an intriguing topic and numerous lines of research have found that a young tissue environment is often more promotional. In fact, a less hospitable promotional tissue environment in older individuals may offset the increased cancer risk associated with the increased mutational load associated with age. Here we address how youthful aspects of angiogenesis, the tumor immune response, and the oxidative stress response may contribute to the rapid progression of EOCRC. Understanding the factors promoting EOCRC may provide insight into why EOCRC cases are increasing.
摘要：
在过去的几十年中，50岁以下患者的结直肠癌（CRC）发病率一直在增加。早期结直肠癌（EOCRC）增加的潜在因素尚不完全清楚。尽管已经注意到晚发性结直肠癌（LOCRC）的一些遗传和临床差异。EOCRC病例通常在更晚期诊断，提高了这些癌症比LOCRC病例进展更快的可能性。年龄对癌症进展的影响是一个有趣的话题，许多研究发现，年轻的组织环境往往更具促进作用。事实上,在老年个体中,不那么好客的推广组织环境可能抵消与年龄相关的突变负荷增加相关的癌症风险增加.在这里，我们讨论血管生成的年轻方面，肿瘤免疫反应，氧化应激反应可能有助于EOCRC的快速进展。了解促进EOCRC的因素可以深入了解EOCRC病例为何增加。
