Abstract：
This paper aims to emphasize the occurrence of various emerging contaminant (EC) mixtures in natural ecosystems and highlights the primary concern arising from the unregulated release into soil and water, along with their impacts on human health. Emerging contaminant mixtures, including pharmaceuticals, personal care products, dioxins, polychlorinated biphenyls, pesticides, antibiotics, biocides, surfactants, phthalates, enteric viruses, and microplastics (MPs), are considered toxic contaminants with grave implications. MPs play a crucial role in transporting pollutants to aquatic and terrestrial ecosystems as they interact with the various components of the soil and water environments. This review summarizes that major emerging contaminants (ECs), like trimethoprim, diclofenac, sulfamethoxazole, and 17α-Ethinylestradiol, pose serious threats to public health and contribute to antimicrobial resistance. In addressing human health concerns and remediation techniques, this review critically evaluates conventional methods for removing ECs from complex matrices. The diverse physiochemical properties of surrounding environments facilitate the partitioning of ECs into sediments and other organic phases, resulting in carcinogenic, teratogenic, and estrogenic effects through active catalytic interactions and mechanisms mediated by aryl hydrocarbon receptors. The proactive toxicity of ECs mixture complexation and, in part, the yet-to-be-identified environmental mixtures of ECs represent a blind spot in current literature, necessitating conceptual frameworks for assessing the toxicity and risks with individual components and mixtures. Lastly, this review concludes with an in-depth exploration of future scopes, knowledge gaps, and challenges, emphasizing the need for a concerted effort in managing ECs and other organic pollutants.
摘要：
本文旨在强调自然生态系统中各种新兴污染物（EC）混合物的发生，并强调了由于不受管制地释放到土壤和水中而引起的主要关注。以及它们对人类健康的影响。新兴的污染物混合物，包括药品,个人护理产品,二恶英,多氯联苯,杀虫剂,抗生素,杀生物剂,表面活性剂，邻苯二甲酸酯,肠道病毒,和微塑料(MPs)，被认为是具有严重影响的有毒污染物。MP在将污染物输送到水生和陆地生态系统中起着至关重要的作用，因为它们与土壤和水环境的各个组成部分相互作用。这篇综述总结了主要的新兴污染物(ECs)，比如甲氧苄啶,双氯芬酸,磺胺甲恶唑,和17α-炔雌醇，对公众健康构成严重威胁，并导致抗菌素耐药性。在解决人类健康问题和补救技术方面，这篇综述严格评估了从复杂基质中去除ECs的常规方法。周围环境的不同物理化学性质促进了ECs向沉积物和其他有机相的分配。导致致癌，致畸,和雌激素效应通过芳香烃受体介导的活性催化作用和机制。ECs混合物络合的主动毒性，在某种程度上,尚未确定的EC的环境混合物代表了当前文献中的一个盲点，需要概念框架来评估单个组分和混合物的毒性和风险。最后,这篇综述最后对未来的范围进行了深入的探索，知识差距，和挑战，强调需要齐心协力管理ECs和其他有机污染物。
