Abstract：
BACKGROUND: Transcranial direct current stimulation (tDCS) is a safe, accessible, and promising therapeutic approach for obsessive-compulsive disorder (OCD).
OBJECTIVE: This study aimed to evaluate the effect of tDCS on electroencephalography (EEG) microstates and identify potential biomarkers to predict efficacy.
METHODS: A total of 24 individuals diagnosed with OCD underwent ten sessions of tDCS targeting the orbitofrontal cortex, while 27 healthy individuals were included as controls. Microstates A, B, C, and D were extracted before and after tDCS. A comparative analysis of microstate metrics was performed between the OCD and the healthy control groups, as well as within the OCD group before and after tDCS. Multiple linear regression analysis was performed to identify potential biomarkers of tDCS.
RESULTS: Comparison to healthy controls, the OCD group exhibited a significantly reduced duration of microstate A and increased occurrence of microstate D. The transition between microstates A and C was significantly different between patients with OCD and healthy controls and was no longer observed following tDCS. Multiple linear regression analysis revealed that the duration of microstate C was associated with an improvement OCD symptom after tDCS.
CONCLUSIONS: The results revealed an aberrant large-scale EEG brain network that could be modulated by tDCS. In particular, the duration of EEG microstate C may be a neurophysiological characteristic associated with the therapeutic effects of tDCS on OCD.
OBJECTIVE: This study aimed to evaluate the effect of tDCS on electroencephalography (EEG) microstates and identify potential biomarkers to predict efficacy.
METHODS: A total of 24 individuals diagnosed with OCD underwent ten sessions of tDCS targeting the orbitofrontal cortex, while 27 healthy individuals were included as controls. Microstates A, B, C, and D were extracted before and after tDCS. A comparative analysis of microstate metrics was performed between the OCD and the healthy control groups, as well as within the OCD group before and after tDCS. Multiple linear regression analysis was performed to identify potential biomarkers of tDCS.
RESULTS: Comparison to healthy controls, the OCD group exhibited a significantly reduced duration of microstate A and increased occurrence of microstate D. The transition between microstates A and C was significantly different between patients with OCD and healthy controls and was no longer observed following tDCS. Multiple linear regression analysis revealed that the duration of microstate C was associated with an improvement OCD symptom after tDCS.
CONCLUSIONS: The results revealed an aberrant large-scale EEG brain network that could be modulated by tDCS. In particular, the duration of EEG microstate C may be a neurophysiological characteristic associated with the therapeutic effects of tDCS on OCD.
摘要：
背景：经颅直流电刺激（tDCS）是一种安全的，可访问,和有希望的强迫症（OCD）的治疗方法。
目的：本研究旨在评估tDCS对脑电图（EEG）微观状态的影响，并确定潜在的生物标志物以预测疗效。
方法：共有24名被诊断为强迫症的患者接受了十次针对眶额皮质的tDCS，而27名健康个体作为对照。微状态A,B,C,在tDCS之前和之后提取D。在强迫症组和健康对照组之间进行了微观状态指标的比较分析，以及tDCS前后的强迫症组内。进行多元线性回归分析以鉴定tDCS的潜在生物标志物。
结果：与健康对照相比，OCD组显示微状态A的持续时间显著缩短,微状态D的发生率增加。OCD患者和健康对照之间的微状态A和C之间的转变显著不同,在tDCS后不再观察到.多元线性回归分析显示，微状态C的持续时间与tDCS后OCD症状的改善有关。
结论：结果揭示了可以通过tDCS调节的异常大规模脑电图脑网络。特别是,EEG微状态C的持续时间可能是与tDCS对OCD的治疗效果相关的神经生理学特征。
目的：本研究旨在评估tDCS对脑电图（EEG）微观状态的影响，并确定潜在的生物标志物以预测疗效。
方法：共有24名被诊断为强迫症的患者接受了十次针对眶额皮质的tDCS，而27名健康个体作为对照。微状态A,B,C,在tDCS之前和之后提取D。在强迫症组和健康对照组之间进行了微观状态指标的比较分析，以及tDCS前后的强迫症组内。进行多元线性回归分析以鉴定tDCS的潜在生物标志物。
结果：与健康对照相比，OCD组显示微状态A的持续时间显著缩短,微状态D的发生率增加。OCD患者和健康对照之间的微状态A和C之间的转变显著不同,在tDCS后不再观察到.多元线性回归分析显示，微状态C的持续时间与tDCS后OCD症状的改善有关。
结论：结果揭示了可以通过tDCS调节的异常大规模脑电图脑网络。特别是,EEG微状态C的持续时间可能是与tDCS对OCD的治疗效果相关的神经生理学特征。
