Abstract：
Psoriasis, a chronic autoimmune skin disorder, causes rapid and excessive skin cell growth due to immune system dysfunction. Numerous studies have shown that flavonoids have anti-psoriatic effects by modulating various molecular mechanisms involved in inflammation, cytokine production, keratinocyte proliferation, and more. This study reviewed experimental data reported in scientific literature and used network analysis to identify the potential biological roles of flavonoids\' targets in treating psoriasis. 947 records from Web of Sciences, ScienceDirect database, Scopus, PubMed, and Cochrane library were reviewed without limitations until June 26, 2023. 66 articles were included in the systematic review. The ten genes with the highest scores, including interleukin (IL)-10, IL-12A, IL-1β, IL-6, Tumor necrosis factor-α (TNF-α), Janus kinase 2 (JAK 2), Jun N-terminal kinase (JUN), Proto-oncogene tyrosine-protein kinase Src (SRC), Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), and Signal transducer and activator of transcription 3 (STAT3), were identified as the hub genes. KEGG pathway analysis identified connections related to inflammation and autoimmune responses, which are key characteristics of psoriasis. IL-6, STAT3, and JUN\'s presence in both hub and enrichment genes suggests their important role in flavonoid\'s effect on psoriasis. This comprehensive study highlights how flavonoids can target biological processes in psoriasis, especially when combined for enhanced effectiveness.
摘要：
牛皮癣,慢性自身免疫性皮肤病,导致快速和过度的皮肤细胞生长由于免疫系统功能障碍。大量研究表明，黄酮类化合物通过调节参与炎症的各种分子机制具有抗银屑病作用，细胞因子产生，角质形成细胞增殖，还有更多.这项研究回顾了科学文献中报道的实验数据，并使用网络分析来确定黄酮类化合物在治疗银屑病中的潜在生物学作用。来自WebofSciences的947条记录,ScienceDirect数据库,Scopus,PubMed,和Cochrane图书馆进行了无限制的审查，直到2023年6月26日。66篇文献纳入系统评价。得分最高的十个基因，包括白细胞介素（IL）-10，IL-12A，IL-1β,IL-6,肿瘤坏死因子-α(TNF-α),Janus激酶2（JAK2），Jun氨基末端激酶（JUN），原癌基因酪氨酸蛋白激酶Src（SRC），磷脂酰肌醇-4,5-二磷酸3-激酶催化亚基α(PIK3CA),和信号转导和转录激活因子3（STAT3），被鉴定为hub基因。KEGG通路分析确定了与炎症和自身免疫反应相关的联系，这是牛皮癣的关键特征。IL-6，STAT3和JUN在hub和富集基因中的存在表明它们在类黄酮对银屑病的作用中具有重要作用。这项全面的研究强调了黄酮类化合物如何靶向银屑病的生物过程，特别是当结合以增强效力时。
