Abstract：
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder associated with insulin resistance (IR) and hyperandrogenaemia (HA). Metabolic inflammation (MI), characterized by a chronic low-grade inflammatory state, is intimately linked with chronic metabolic diseases such as IR and diabetes and is also considered an essential factor in the development of PCOS. Insulin-like growth factor 1 (IGF-1) plays an essential role in PCOS pathogenesis through its multiple functions in regulating cell proliferation metabolic processes and reducing inflammatory responses. This review summarizes the molecular mechanisms by which IGF-1, via MI, participates in the onset and progression of PCOS, aiming to provide insights for studies and clinical treatment of PCOS.
摘要：
多囊卵巢综合征（PCOS）是一种常见的与胰岛素抵抗（IR）和高雄激素血症（HA）相关的内分泌疾病。代谢性炎症(MI),以慢性低度炎症状态为特征，与IR和糖尿病等慢性代谢性疾病密切相关，也被认为是PCOS发展的重要因素。胰岛素样生长因子1(IGF-1)通过调节细胞增殖代谢过程和减轻炎症反应等多种功能在PCOS发病机制中发挥重要作用。这篇综述总结了IGF-1通过MI，参与PCOS的发病和进展，旨在为PCOS的研究和临床治疗提供见解。
