关键词: ethosome inflammation skin topical administration transdermal delivery transethosome

Mesh : Humans Administration, Cutaneous Animals Skin / metabolism Drug Delivery Systems Skin Absorption

来  源:   DOI:10.1146/annurev-food-072023-034528

Abstract:
Because the feeding of our body through the oral route can be associated with many drawbacks due to the degradation of natural molecules during transit in the gastrointestinal tract, a transdermal delivery strategy, usually employed in the pharmaceutical field, can present an effective alternative for delivery of bioactives and nutrients from foods. In this review, the chance to feed the body with nutritive and bioactive molecules from food through transdermal administration is discussed. Various nanotechnological devices employed for topical and transdermal delivery of bioactive compounds are described. In addition, mechanisms underlying their potential use in the delivery of nutritive molecules, as well as their capability to efficaciously reach the dermis and promote systemic distribution, are detailed.
摘要:
因为通过口服途径喂养我们的身体可能会由于天然分子在胃肠道运输过程中的降解而带来许多缺点,透皮给药策略,通常用于制药领域,可以提供从食物中递送生物活性物质和营养素的有效替代方案。在这次审查中,讨论了通过透皮给药从食物中摄取营养和生物活性分子的机会。描述了用于局部和透皮递送生物活性化合物的各种纳米技术装置。此外,它们在营养分子输送中潜在用途的潜在机制,以及它们有效到达真皮并促进全身分布的能力,是详细的。
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