PDF(Pubmed)
Abstract：
UNASSIGNED: Studies on the familial effects of body mass index (BMI) status have yielded a wide range of data on its heritability.
UNASSIGNED: To assess the heritability of obesity by measuring the association between the BMIs of fathers, mothers, and their offspring at the same age.
UNASSIGNED: This cohort study used data from population-wide mandatory medical screening before compulsory military service in Israel. The study included participants examined between January 1, 1986, and December 31, 2018, whose both parents had their BMI measurement taken at their own prerecruitment evaluation in the past. Data analysis was performed from May to December 2023.
UNASSIGNED: Spearman correlation coefficients were calculated for offsprings\' BMI and their mothers\', fathers\', and midparental BMI percentile (the mean of the mothers\' and fathers\' BMI cohort- and sex-specific BMI percentile) to estimate heritability. Logistic regression models were applied to estimate the odds ratios (ORs) and 95% CIs of obesity compared with healthy BMI, according to parental BMI status.
UNASSIGNED: A total of 447 883 offspring (235 105 male [52.5%]; mean [SD] age, 17.09 [0.34] years) with both parents enrolled and measured for BMI at 17 years of age were enrolled in the study, yielding a total study population of 1 343 649 individuals. Overall, the correlation between midparental BMI percentile at 17 years of age and the offspring\'s BMI at 17 years of age was moderate (ρ = 0.386). Among female offspring, maternal-offspring BMI correlation (ρ = 0.329) was somewhat higher than the paternal-offspring BMI correlation (ρ = 0.266). Among trios in which both parents had a healthy BMI, the prevalence of overweight or obesity in offspring was 15.4%; this proportion increased to 76.6% when both parents had obesity and decreased to 3.3% when both parents had severe underweight. Compared with healthy weight, maternal (OR, 4.96; 95% CI, 4.63-5.32), paternal (OR, 4.48; 95% CI, 4.26-4.72), and parental (OR, 6.44; 95% CI, 6.22-6.67) obesity (midparent BMI in the ≥95th percentile) at 17 years of age were associated with increased odds of obesity among offspring.
UNASSIGNED: In this cohort study of military enrollees whose parents also underwent prerecruitment evaluations, the observed correlation between midparental and offspring BMI, coupled with a calculated narrow-sense heritability of 39%, suggested a substantive contribution of genetic factors to BMI variation at 17 years of age.
UNASSIGNED: To assess the heritability of obesity by measuring the association between the BMIs of fathers, mothers, and their offspring at the same age.
UNASSIGNED: This cohort study used data from population-wide mandatory medical screening before compulsory military service in Israel. The study included participants examined between January 1, 1986, and December 31, 2018, whose both parents had their BMI measurement taken at their own prerecruitment evaluation in the past. Data analysis was performed from May to December 2023.
UNASSIGNED: Spearman correlation coefficients were calculated for offsprings\' BMI and their mothers\', fathers\', and midparental BMI percentile (the mean of the mothers\' and fathers\' BMI cohort- and sex-specific BMI percentile) to estimate heritability. Logistic regression models were applied to estimate the odds ratios (ORs) and 95% CIs of obesity compared with healthy BMI, according to parental BMI status.
UNASSIGNED: A total of 447 883 offspring (235 105 male [52.5%]; mean [SD] age, 17.09 [0.34] years) with both parents enrolled and measured for BMI at 17 years of age were enrolled in the study, yielding a total study population of 1 343 649 individuals. Overall, the correlation between midparental BMI percentile at 17 years of age and the offspring\'s BMI at 17 years of age was moderate (ρ = 0.386). Among female offspring, maternal-offspring BMI correlation (ρ = 0.329) was somewhat higher than the paternal-offspring BMI correlation (ρ = 0.266). Among trios in which both parents had a healthy BMI, the prevalence of overweight or obesity in offspring was 15.4%; this proportion increased to 76.6% when both parents had obesity and decreased to 3.3% when both parents had severe underweight. Compared with healthy weight, maternal (OR, 4.96; 95% CI, 4.63-5.32), paternal (OR, 4.48; 95% CI, 4.26-4.72), and parental (OR, 6.44; 95% CI, 6.22-6.67) obesity (midparent BMI in the ≥95th percentile) at 17 years of age were associated with increased odds of obesity among offspring.
UNASSIGNED: In this cohort study of military enrollees whose parents also underwent prerecruitment evaluations, the observed correlation between midparental and offspring BMI, coupled with a calculated narrow-sense heritability of 39%, suggested a substantive contribution of genetic factors to BMI variation at 17 years of age.
摘要：
■关于体重指数（BMI）状态的家族效应的研究已经获得了有关其遗传力的广泛数据。
■为了通过测量父亲的BMI之间的关联来评估肥胖的遗传性，母亲们,和他们同龄的后代。
■这项队列研究使用了以色列服兵役前的全人群强制性医疗筛查数据。该研究包括1986年1月1日至2018年12月31日期间接受检查的参与者，他们的父母都在过去的招募前评估中进行了BMI测量。数据分析于2023年5月至12月进行。
■计算了后代“BMI及其母亲”的Spearman相关系数，父亲\'，和中父母BMI百分位数（母亲和父亲BMI队列的平均值和性别特定的BMI百分位数）来估计遗传力。应用Logistic回归模型估算肥胖与健康BMI相比的比值比(OR)和95%CI,根据父母的BMI状况。
■共有447883个后代（235105个雄性[52.5％]；平均[SD]年龄，17.09[0.34]年），父母双方都参加了研究，并在17岁时测量了BMI，产生的总研究群体为1343649人。总的来说,17岁时父母中BMI百分位数与17岁时后代BMI的相关性中等(ρ=0.386)。在雌性后代中，母子BMI相关性（ρ=0.329）略高于父子BMI相关性（ρ=0.266）。在父母双方都有健康BMI的三重奏中，后代超重或肥胖的患病率为15.4%;当父母双方都有肥胖时,这一比例增加到76.6%;当父母双方都有严重体重不足时,这一比例下降到3.3%.与健康体重相比，母体（或，4.96；95%CI，4.63-5.32)，父系（或，4.48；95%CI，4.26-4.72），和父母(或，6.44;95%CI,6.22-6.67)17岁时肥胖(≥95百分位数的中亲BMI)与后代肥胖几率增加相关。
■在这项针对军人的队列研究中，他们的父母也接受了征兵前评估，观察到的中亲和后代BMI之间的相关性，再加上计算得出的39%的狭义遗传力，表明遗传因素对17岁时的BMI变异有实质性贡献。
■为了通过测量父亲的BMI之间的关联来评估肥胖的遗传性，母亲们,和他们同龄的后代。
■这项队列研究使用了以色列服兵役前的全人群强制性医疗筛查数据。该研究包括1986年1月1日至2018年12月31日期间接受检查的参与者，他们的父母都在过去的招募前评估中进行了BMI测量。数据分析于2023年5月至12月进行。
■计算了后代“BMI及其母亲”的Spearman相关系数，父亲\'，和中父母BMI百分位数（母亲和父亲BMI队列的平均值和性别特定的BMI百分位数）来估计遗传力。应用Logistic回归模型估算肥胖与健康BMI相比的比值比(OR)和95%CI,根据父母的BMI状况。
■共有447883个后代（235105个雄性[52.5％]；平均[SD]年龄，17.09[0.34]年），父母双方都参加了研究，并在17岁时测量了BMI，产生的总研究群体为1343649人。总的来说,17岁时父母中BMI百分位数与17岁时后代BMI的相关性中等(ρ=0.386)。在雌性后代中，母子BMI相关性（ρ=0.329）略高于父子BMI相关性（ρ=0.266）。在父母双方都有健康BMI的三重奏中，后代超重或肥胖的患病率为15.4%;当父母双方都有肥胖时,这一比例增加到76.6%;当父母双方都有严重体重不足时,这一比例下降到3.3%.与健康体重相比，母体（或，4.96；95%CI，4.63-5.32)，父系（或，4.48；95%CI，4.26-4.72），和父母(或，6.44;95%CI,6.22-6.67)17岁时肥胖(≥95百分位数的中亲BMI)与后代肥胖几率增加相关。
■在这项针对军人的队列研究中，他们的父母也接受了征兵前评估，观察到的中亲和后代BMI之间的相关性，再加上计算得出的39%的狭义遗传力，表明遗传因素对17岁时的BMI变异有实质性贡献。
