Abstract：
Some previous researches have demonstrated that appropriate mechanical stimulation can enhance bone formation. However, most studies have employed the strain energy density (SED) method for predicting bone remodeling, with only a few considering the potential impact of wall fluid shear stress (FSS) on this process. To bridge this gap, the current study compared the prediction of bone formation and resorption via SED and wall FSS by using fluid-solid coupling numerical simulation. Specifically, 8-week-old female Sprague-Dawley rats were subjected to stretching of the eighth caudal vertebra using a custom-made device. Based on micro-computed tomography images, a three-dimensional model integrating fluid-solid coupling was created to represent compact bone, cancellous bone, and bone marrow. The animals were grouped into control, 1 Hz, and 10 Hz categories, wherein a tensile displacement load of 1000 με was applied to the loading end. The results revealed that SED values tended to increase with elevated porosity, whereas wall FSS values decreased it. Notably, wall FSS demonstrated the higher predictive accuracy for cancellous bone resorption than SED. These findings support the notion that fluid flow within cancellous bone spaces can significantly impact bone resorption. Therefore, the findings of this study contribute to a more comprehensive understanding of the role of wall FSS in bone remodeling, providing a theoretical support for the dynamic evolution of bone structures under mechanical stimulation.
摘要：
先前的一些研究表明，适当的机械刺激可以增强骨形成。然而,大多数研究都采用应变能密度(SED)方法来预测骨重建，只有少数人考虑了壁面流体剪切应力（FSS）对这一过程的潜在影响。为了弥合这个差距，目前的研究通过流固耦合数值模拟比较了通过SED和壁FSS的骨形成和吸收的预测。具体来说,使用定制的装置对8周大的雌性Sprague-Dawley大鼠进行第八尾椎的拉伸。基于显微计算机断层扫描图像，创建了一个集成流固耦合的三维模型来表示致密的骨骼，松质骨,还有骨髓.将动物分组为对照组，1Hz,和10Hz类别，其中将1000με的拉伸位移载荷施加到加载端。结果表明，随着孔隙率的升高，SED值趋于增加，而墙壁FSS值降低了它。值得注意的是,FSS对松质骨吸收的预测准确性高于SED。这些发现支持松质骨空间内的流体流动可以显着影响骨吸收的观点。因此,这项研究的发现有助于更全面地了解壁FSS在骨重建中的作用，为机械刺激下骨结构的动态演化提供了理论支持。
