Abstract：
OBJECTIVE: The burden of epilepsy is complex and consists of elements directly related to acute seizures as well as those associated with living with a chronic neurologic disorder. The purpose of this systematic review was to characterize short-term burdens of seizures and to explore the potential value of acute treatments to mitigate these burdens apart from reducing the risk of status epilepticus.
RESULTS: A systematic literature search was conducted using PubMed to identify articles published from January 1, 2017, to June 22, 2023, that described short-term burdens and acute treatments of seizures. Primary outcomes included those related to short-term burdens of seizures and the benefits of acute treatments to reduce short-term burdens. Of the 1332 articles identified through PubMed and 17 through other sources, 27 had relevant outcomes and were included in the qualitative synthesis. Seizure emergencies negatively affected short-term quality of life and the ability to conduct normal daily living activities and were associated with physical (injury) and financial (emergency transport, hospitalization) burdens. The use of acute treatment was associated with a rapid return (≤ 1 h) to normal function/self for both patients and caregivers and potentially lower healthcare utilization and costs. Seizure action plans may improve knowledge and comfort with seizure care, empowering patients and caregivers. The short-term burden of seizures can create a substantial negative impact on patients and caregivers. Acute treatments may reduce the short-term burdens of seizures in addition to their well-described role to reduce seizure activity and the risk for status epilepticus.
RESULTS: A systematic literature search was conducted using PubMed to identify articles published from January 1, 2017, to June 22, 2023, that described short-term burdens and acute treatments of seizures. Primary outcomes included those related to short-term burdens of seizures and the benefits of acute treatments to reduce short-term burdens. Of the 1332 articles identified through PubMed and 17 through other sources, 27 had relevant outcomes and were included in the qualitative synthesis. Seizure emergencies negatively affected short-term quality of life and the ability to conduct normal daily living activities and were associated with physical (injury) and financial (emergency transport, hospitalization) burdens. The use of acute treatment was associated with a rapid return (≤ 1 h) to normal function/self for both patients and caregivers and potentially lower healthcare utilization and costs. Seizure action plans may improve knowledge and comfort with seizure care, empowering patients and caregivers. The short-term burden of seizures can create a substantial negative impact on patients and caregivers. Acute treatments may reduce the short-term burdens of seizures in addition to their well-described role to reduce seizure activity and the risk for status epilepticus.
摘要：
目的：癫痫的负担是复杂的，包括与急性癫痫发作直接相关的因素以及与慢性神经系统疾病相关的因素。本系统评价的目的是描述癫痫发作的短期负担，并探讨急性治疗除了降低癫痫持续状态的风险外，减轻这些负担的潜在价值。
结果：使用PubMed进行了系统的文献检索，以确定从2017年1月1日至2023年6月22日发表的文章，这些文章描述了癫痫发作的短期负担和急性治疗。主要结果包括与癫痫发作的短期负担和急性治疗以减少短期负担有关的结果。在通过PubMed确定的1332篇文章和通过其他来源确定的17篇文章中，27例具有相关结果，并被纳入定性综合。癫痫紧急情况对短期生活质量和进行正常日常生活活动的能力产生负面影响，并与身体(伤害)和财务(紧急运输，住院)负担。急性治疗的使用与患者和护理人员快速恢复（≤1小时）至正常功能/自我相关，并可能降低医疗保健利用率和成本。癫痫发作行动计划可以提高癫痫发作护理的知识和舒适度，赋予患者和护理人员权力。癫痫发作的短期负担可能对患者和护理人员产生重大负面影响。急性治疗除了其充分描述的减少癫痫发作活动和癫痫持续状态风险的作用外，还可以减少癫痫发作的短期负担。
结果：使用PubMed进行了系统的文献检索，以确定从2017年1月1日至2023年6月22日发表的文章，这些文章描述了癫痫发作的短期负担和急性治疗。主要结果包括与癫痫发作的短期负担和急性治疗以减少短期负担有关的结果。在通过PubMed确定的1332篇文章和通过其他来源确定的17篇文章中，27例具有相关结果，并被纳入定性综合。癫痫紧急情况对短期生活质量和进行正常日常生活活动的能力产生负面影响，并与身体(伤害)和财务(紧急运输，住院)负担。急性治疗的使用与患者和护理人员快速恢复（≤1小时）至正常功能/自我相关，并可能降低医疗保健利用率和成本。癫痫发作行动计划可以提高癫痫发作护理的知识和舒适度，赋予患者和护理人员权力。癫痫发作的短期负担可能对患者和护理人员产生重大负面影响。急性治疗除了其充分描述的减少癫痫发作活动和癫痫持续状态风险的作用外，还可以减少癫痫发作的短期负担。
