Abstract：
OBJECTIVE: Fear of progression (FoP) leads to poor clinical outcomes in colorectal cancer patients. The study aimed to clarify the profiles and influencing factors of FoP among colorectal cancer patients.
METHODS: A cross-sectional study was conducted with 409 colorectal cancer patients. Convenience sampling method was used to select colorectal cancer patients hospitalized in a tertiary-level hospital in Nanjing as the survey subjects. General information questionnaire, Fear of Progression Questionnaire-Short Form, Distress Disclosure Index, and Social Support Rating Scale were used to collect the data. Latent profile analysis was used to explore the latent profiles of FoP in colorectal cancer patients. Additionally, the influencing factors of profiles were explored by Univariate Analysis and Binomial Logistic Regression Analysis.
RESULTS: Latent profile analysis identified two subgroups of fear of disease progression: the \"fear low-risk profile (83%)\", and the \"severe fear profile (17%).\" Patients with low age, low social support utilization, first hospital admission, severe healthcare burden, and preoperative bowel symptoms were prone to severe fear of disease progression.
CONCLUSIONS: There is some heterogeneity in the level of postoperative fear of disease progression in colorectal cancer patients. Doctors and nurses should focus on patients with severe fear and take targeted preventive and psychological care for patients\' fear of disease progression as early as possible according to the distribution characteristics of different categories.
METHODS: A cross-sectional study was conducted with 409 colorectal cancer patients. Convenience sampling method was used to select colorectal cancer patients hospitalized in a tertiary-level hospital in Nanjing as the survey subjects. General information questionnaire, Fear of Progression Questionnaire-Short Form, Distress Disclosure Index, and Social Support Rating Scale were used to collect the data. Latent profile analysis was used to explore the latent profiles of FoP in colorectal cancer patients. Additionally, the influencing factors of profiles were explored by Univariate Analysis and Binomial Logistic Regression Analysis.
RESULTS: Latent profile analysis identified two subgroups of fear of disease progression: the \"fear low-risk profile (83%)\", and the \"severe fear profile (17%).\" Patients with low age, low social support utilization, first hospital admission, severe healthcare burden, and preoperative bowel symptoms were prone to severe fear of disease progression.
CONCLUSIONS: There is some heterogeneity in the level of postoperative fear of disease progression in colorectal cancer patients. Doctors and nurses should focus on patients with severe fear and take targeted preventive and psychological care for patients\' fear of disease progression as early as possible according to the distribution characteristics of different categories.
摘要：
目的：对进展的恐惧（FoP）导致结直肠癌患者的临床预后不良。本研究旨在阐明FoP在结直肠癌患者中的分布及影响因素。
方法：对409例结直肠癌患者进行了一项横断面研究。采用便利抽样法选取南京某三级医院住院的结直肠癌患者作为调查对象。一般信息问卷，对进展的恐惧问卷-简表，困境披露指数，使用社会支持评定量表收集数据。潜在谱分析用于探索FoP在结直肠癌患者中的潜在概况。此外,采用单因素分析和二项Logistic回归分析对影响因素进行分析。
结果：潜在特征分析确定了对疾病进展的恐惧的两个亚组：“恐惧低风险特征（83％）”，和“严重恐惧”(17%)。“年龄低的患者，社会支持利用率低，第一次住院，严重的医疗负担，术前肠道症状容易引起对疾病进展的严重恐惧。
结论：结直肠癌患者术后对疾病进展的恐惧水平存在一定的异质性。医护人员应针对严重恐惧症患者，根据不同类别的分布特点，尽早采取针对性的预防和心理护理措施。
方法：对409例结直肠癌患者进行了一项横断面研究。采用便利抽样法选取南京某三级医院住院的结直肠癌患者作为调查对象。一般信息问卷，对进展的恐惧问卷-简表，困境披露指数，使用社会支持评定量表收集数据。潜在谱分析用于探索FoP在结直肠癌患者中的潜在概况。此外,采用单因素分析和二项Logistic回归分析对影响因素进行分析。
结果：潜在特征分析确定了对疾病进展的恐惧的两个亚组：“恐惧低风险特征（83％）”，和“严重恐惧”(17%)。“年龄低的患者，社会支持利用率低，第一次住院，严重的医疗负担，术前肠道症状容易引起对疾病进展的严重恐惧。
结论：结直肠癌患者术后对疾病进展的恐惧水平存在一定的异质性。医护人员应针对严重恐惧症患者，根据不同类别的分布特点，尽早采取针对性的预防和心理护理措施。
