PDF(Pubmed)
Abstract：
Whether cancer cells metastasize from the primary site to the distant sites via the lymphatic vessels or the blood vessels directly into the circulation is still under intense study. In this review article, we follow the journey of cancer cells metastasizing to the sentinel lymph nodes and beyond to the distant sites. We emphasize cancer heterogeneity and microenvironment as major determinants of cancer metastasis. Multiple molecules have been found to be associated with the complicated process of metastasis. Based on the large sentinel lymph node data, it is reasonable to conclude that cancer cells may metastasize through the blood vessels in some cases but in most cases, they use the sentinel lymph nodes as the major gateway to enter the circulation to distant sites.
摘要：
癌细胞是否通过淋巴管从原发部位转移到远处部位或血管直接进入循环仍在深入研究中。在这篇评论文章中，我们跟随癌细胞转移到前哨淋巴结和远处的旅程。我们强调癌症异质性和微环境是癌症转移的主要决定因素。已发现多种分子与复杂的转移过程有关。根据巨大的前哨淋巴结数据,可以合理地得出结论，在某些情况下，癌细胞可能会通过血管转移，但在大多数情况下，他们使用前哨淋巴结作为进入血液循环到远处的主要通道。
