Abstract：
BACKGROUND: Many patients who have undergone surgery experience persistent pain after breast cancer treatment (PPBCT). These symptoms often remain unnoticed by treating physician(s), and the pathophysiology of PPBCT remains poorly understood. The purpose of this study was to determine prevalence of PPBCT and examine the association between PPBCT and various patient, tumor, and treatment characteristics.
METHODS: We conducted a questionnaire-based cross-sectional study enrolling patients with breast cancer treated at Máxima Medical Center between 2005 and 2016. PPBCT was defined as pain in the breast, anterior thorax, axilla, and/or medial upper arm that persists for at least 3 months after surgery. Tumor and treatment characteristics were derived from the Dutch Cancer Registry and electronic patient files.
RESULTS: Between February and March 2019, a questionnaire was sent to 2022 women, of whom 56.5% responded. Prevalence of PPBCT among the responders was 37.9%, with 50.8% reporting moderate to severe pain. Multivariable analyses showed that women with signs of anxiety, depression or a history of smoking had a higher risk of experiencing PPBCT. Women aged 70 years or older at diagnosis were significantly less likely to report PPBCT compared with younger women. No significant association was found between PPBCT and treatment characteristics, including type of axillary surgery and radiotherapy.
CONCLUSIONS: A considerable percentage of patients with breast cancer experience PPBCT. Women with signs of anxiety or depression and women with a history of smoking are more likely to report PPBCT. Further research is required to understand the underlying etiology and to improve prevention and treatment strategies for PPBCT.
METHODS: We conducted a questionnaire-based cross-sectional study enrolling patients with breast cancer treated at Máxima Medical Center between 2005 and 2016. PPBCT was defined as pain in the breast, anterior thorax, axilla, and/or medial upper arm that persists for at least 3 months after surgery. Tumor and treatment characteristics were derived from the Dutch Cancer Registry and electronic patient files.
RESULTS: Between February and March 2019, a questionnaire was sent to 2022 women, of whom 56.5% responded. Prevalence of PPBCT among the responders was 37.9%, with 50.8% reporting moderate to severe pain. Multivariable analyses showed that women with signs of anxiety, depression or a history of smoking had a higher risk of experiencing PPBCT. Women aged 70 years or older at diagnosis were significantly less likely to report PPBCT compared with younger women. No significant association was found between PPBCT and treatment characteristics, including type of axillary surgery and radiotherapy.
CONCLUSIONS: A considerable percentage of patients with breast cancer experience PPBCT. Women with signs of anxiety or depression and women with a history of smoking are more likely to report PPBCT. Further research is required to understand the underlying etiology and to improve prevention and treatment strategies for PPBCT.
摘要：
背景：许多接受手术的患者在乳腺癌治疗（PPBCT）后经历持续性疼痛。这些症状通常不被治疗医生注意到，和PPBCT的病理生理学仍然知之甚少。这项研究的目的是确定PPBCT的患病率，并检查PPBCT与不同患者之间的关联。肿瘤，和治疗特点。
方法：我们进行了一项基于问卷调查的横断面研究，招募了2005年至2016年在Máxima医学中心接受治疗的乳腺癌患者。PPBCT被定义为乳房疼痛，前胸部,腋下,和/或手术后持续至少3个月的上臂内侧。肿瘤和治疗特征来自荷兰癌症登记处和电子患者档案。
结果：在2019年2月至3月之间，向2022名女性发送了一份问卷，其中56.5%的人回答。应答者中PPBCT的患病率为37.9%，50.8%报告中度至重度疼痛。多变量分析表明，有焦虑迹象的女性，抑郁症或有吸烟史的患者患PPBCT的风险较高.与年轻女性相比，诊断为70岁或以上的女性报告PPBCT的可能性明显较小。在PPBCT和治疗特征之间没有发现显著关联。包括腋窝手术和放疗类型。
结论：相当比例的乳腺癌患者经历过PPBCT。有焦虑或抑郁迹象的女性和有吸烟史的女性更有可能报告PPBCT。需要进一步的研究来了解潜在的病因并改善PPBCT的预防和治疗策略。
方法：我们进行了一项基于问卷调查的横断面研究，招募了2005年至2016年在Máxima医学中心接受治疗的乳腺癌患者。PPBCT被定义为乳房疼痛，前胸部,腋下,和/或手术后持续至少3个月的上臂内侧。肿瘤和治疗特征来自荷兰癌症登记处和电子患者档案。
结果：在2019年2月至3月之间，向2022名女性发送了一份问卷，其中56.5%的人回答。应答者中PPBCT的患病率为37.9%，50.8%报告中度至重度疼痛。多变量分析表明，有焦虑迹象的女性，抑郁症或有吸烟史的患者患PPBCT的风险较高.与年轻女性相比，诊断为70岁或以上的女性报告PPBCT的可能性明显较小。在PPBCT和治疗特征之间没有发现显著关联。包括腋窝手术和放疗类型。
结论：相当比例的乳腺癌患者经历过PPBCT。有焦虑或抑郁迹象的女性和有吸烟史的女性更有可能报告PPBCT。需要进一步的研究来了解潜在的病因并改善PPBCT的预防和治疗策略。
