Abstract：
Traumatic spinal cord injury (SCI) is a serious disease of the central nervous system. Aside from the limited intrinsic regenerative capacity of neurons, complex microenvironmental disturbances can also lead to further cellular damage and growth inhibition. Programmed cell death regulated by pyroptosis has an important role in the pathogenesis of SCI. While there has been a wealth of new knowledge regarding cellular pyroptosis, a detailed understanding of its role in SCI and possible therapeutic strategies is still lacking. This review summarizes current advances in the regulatory role of pyroptosis-regulated cell death and inflammasome components in the inhibitory microenvironment following SCI, as well as recent therapeutic advances.
摘要：
创伤性脊髓损伤(SCI)是一种严重的中枢神经系统疾病。除了有限的神经元内在再生能力，复杂的微环境干扰也可能导致进一步的细胞损伤和生长抑制。细胞凋亡调控的程序性死亡在SCI的发病机制中具有重要作用。虽然有大量关于细胞焦亡的新知识，目前仍缺乏对其在SCI中的作用和可能的治疗策略的详细了解.这篇综述总结了SCI后抑制性微环境中焦凋亡调节的细胞死亡和炎性小体成分的调节作用的最新进展，以及最近的治疗进展。
