关键词: Alzheimer's disease acetylcholine. bio-actives natural products neurotransmitters

来  源:   DOI:10.2174/0118715249307525240614073143

Abstract:
More than 20 million people worldwide have Alzheimer\'s disease (AD), making it the most prevalent disease. Patients with AD may live for at least a decade after diagnosis, making it the most common cause of disability in the elderly. Each year, 1% to 4% of the population is affected by AD, with prevalence peaking between ages 65 and 70 and declining to 6% among those over 85. Researchers have accumulated evidence on medicinal herbs that may reverse the pathogenesis of Alzheimer\'s disease. Alzheimer\'s disease (AD) is associated with severe memory loss, which can negatively impact social and professional life. The first neurotransmitter linked to Alzheimer\'s was acetylcholine (ACh). There is no known cure, and the available treatments are ineffective. Multiple studies indicate that Ayurvedic restorative herbs and their constituents may be effective in treating Alzheimer\'s disease. This technique emphasizes the fact that delaying or preventing Alzheimer\'s disease with the help of natural bio-actives could reduce the number of cases over the next half-century. To provide detailed information, the pathology and pathophysiology of Alzheimer\'s Disease are discussed in the text of this review, along with an overview of the neurotransmitters involved in the progression of the disease. The importance of different natural bioactives for the treatment of Alzheimer\'s disease is also outlined in the paper. The information contained in this paper can serve as a template for future research expressing the more beneficial role of other bioactive in acting as an adjuvant in the prevention and treatment of this disease, facing certain challenges and gaps with conventional drugs used to treat Alzheimer\'s disease.
摘要:
全世界有超过2000万人患有阿尔茨海默病(AD)。使其成为最普遍的疾病。患有AD的患者可能在诊断后存活至少十年,使其成为老年人残疾的最常见原因。每一年,1%~4%的人群受AD影响,患病率在65至70岁之间达到峰值,在85岁以上的人群中下降到6%。研究人员已经积累了关于可能逆转阿尔茨海默病发病机制的草药的证据。阿尔茨海默病(AD)与严重的记忆丧失有关,这会对社会和职业生活产生负面影响。与阿尔茨海默氏症相关的第一个神经递质是乙酰胆碱(ACh)。没有已知的治疗方法,可用的治疗方法是无效的。多项研究表明,阿育吠陀修复草药及其成分可能有效治疗阿尔茨海默病。这种技术强调了这样一个事实,即在天然生物活性物质的帮助下延缓或预防阿尔茨海默病可以减少未来半个世纪的病例数。为了提供详细信息,本文对阿尔茨海默病的病理学和病理生理学进行了讨论,以及与疾病进展有关的神经递质的概述。本文还概述了不同天然生物活性物质对治疗阿尔茨海默病的重要性。本文中包含的信息可以作为未来研究的模板,表达其他生物活性物质在预防和治疗这种疾病中作为佐剂的更有益的作用。与用于治疗阿尔茨海默病的常规药物面临某些挑战和差距。
公众号