Abstract：
As a multifunctional adipokine, chemerin plays a crucial role in various pathophysiological processes through endocrine and paracrine manner. It can bind to three known receptors (ChemR23, GPR1 and CCRL2) and participate in energy metabolism, glucose and lipid metabolism, and inflammation, especially in metabolic diseases. Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases, which seriously affects the normal life of women of childbearing age. Patients with PCOS have significantly increased serum levels of chemerin and high expression of chemerin in their ovaries. More and more studies have shown that chemerin is involved in the occurrence and development of PCOS by affecting obesity, insulin resistance, hyperandrogenism, oxidative stress and inflammatory response. This article mainly reviews the production, subtypes, function and receptors of chemerin protein, summarizes and discusses the research status of chemerin protein in PCOS from the perspectives of metabolism, reproduction and inflammation, and provides theoretical basis and reference for the clinical diagnosis and treatment of PCOS.
摘要：
作为一种多功能脂肪因子,chemerin通过内分泌和旁分泌方式在各种病理生理过程中起着至关重要的作用。它可以与三种已知的受体（ChemR23、GPR1和CCRL2）结合，参与能量代谢，葡萄糖和脂质代谢，和炎症，尤其是在代谢性疾病中。多囊卵巢综合征(PCOS)是最常见的内分泌疾病之一。严重影响育龄妇女的正常生活。PCOS患者的血清chemerin水平显著升高，卵巢chemerin高表达。越来越多的研究表明,Chemerin通过影响肥胖参与PCOS的发生发展,胰岛素抵抗，雄激素过多症,氧化应激和炎症反应。本文主要回顾了生产，亚型，chemerin蛋白的功能和受体，从代谢的角度总结和讨论了chemerin蛋白在PCOS中的研究现状,生殖和炎症，为PCOS的临床诊治提供理论依据和参考。
