PDF(Pubmed)
Abstract：
UNASSIGNED: Identifying risk factors for venous thromboembolism (VTE) is useful in deciding thromboprophylaxis for VTE. A retrospective study had shown an association between hypertension and diabetes mellitus with VTE in our population. The objective of this study was to confirm these findings and to determine if the complete blood count and coagulation tests can also be useful parameters in stratifying VTE patients for prophylaxis.
UNASSIGNED: This is a gender and age matched prospective case-control study of 45 Doppler\'s confirmed DVT and 43 apparently healthy controls.
UNASSIGNED: Identified risk factors included history of hypertension, diabetes mellitus, previous DVT, recent surgery, recent trauma, malignancy, sepsis, and immobility. The cases had a significantly lower mean haematocrit (33±7.4% vs 38±4.6%, p<0.001). Though no differences were observed in leucocyte and platelet counts between cases and controls but stratification as leucocytosis vs leucopaenia (P=0.003) and thrombocytosis vs thrombocytopaenia (P=0.045) differed between both groups. Also, the International normalized ratio (INR) was higher in cases (1.1±0.2 vs 1.0±0.1;P=0.001), hypercoagulable state (INR<0.9) and hypocoagulable state (INR>1.2) were observed in 4.4% and 28.9% of cases respectively but not in controls (P <0.001). Also, aPTT>40 seconds was seen in 4.4% vs 4.7% of cases and controls respectively and aPTT< 30 seconds in 22% of cases but not in controls (P =0.004).
UNASSIGNED: Hypertension and diabetes mellitus are identified risk factors not traditionally associated with DVT. These in addition to a complete blood count and coagulation tests can be useful in stratifying patients for prophylaxis in our population and other similar communities.
UNASSIGNED: This is a gender and age matched prospective case-control study of 45 Doppler\'s confirmed DVT and 43 apparently healthy controls.
UNASSIGNED: Identified risk factors included history of hypertension, diabetes mellitus, previous DVT, recent surgery, recent trauma, malignancy, sepsis, and immobility. The cases had a significantly lower mean haematocrit (33±7.4% vs 38±4.6%, p<0.001). Though no differences were observed in leucocyte and platelet counts between cases and controls but stratification as leucocytosis vs leucopaenia (P=0.003) and thrombocytosis vs thrombocytopaenia (P=0.045) differed between both groups. Also, the International normalized ratio (INR) was higher in cases (1.1±0.2 vs 1.0±0.1;P=0.001), hypercoagulable state (INR<0.9) and hypocoagulable state (INR>1.2) were observed in 4.4% and 28.9% of cases respectively but not in controls (P <0.001). Also, aPTT>40 seconds was seen in 4.4% vs 4.7% of cases and controls respectively and aPTT< 30 seconds in 22% of cases but not in controls (P =0.004).
UNASSIGNED: Hypertension and diabetes mellitus are identified risk factors not traditionally associated with DVT. These in addition to a complete blood count and coagulation tests can be useful in stratifying patients for prophylaxis in our population and other similar communities.
摘要：
■确定静脉血栓栓塞（VTE）的危险因素有助于决定VTE的血栓预防。一项回顾性研究表明，在我们的人群中，高血压和糖尿病与VTE之间存在关联。这项研究的目的是确认这些发现，并确定完整的血细胞计数和凝血测试是否也可以作为对VTE患者进行分层预防的有用参数。
■这是一项性别和年龄匹配的前瞻性病例对照研究，研究对象为45例多普勒证实的DVT和43例明显健康的对照。
■确定的危险因素包括高血压病史，糖尿病,以前的DVT,最近的手术,最近的创伤,恶性肿瘤，脓毒症,和不动。这些病例的平均血细胞比容显着降低（33±7.4％vs38±4.6％，p<0.001)。尽管在病例和对照组之间没有观察到白细胞和血小板计数的差异，但两组之间的白细胞增多与白细胞减少（P=0.003）和血小板增多与血小板减少（P=0.045）分层存在差异。此外，病例中国际标准化比率（INR）较高（1.1±0.2vs1.0±0.1；P=0.001），分别在4.4%和28.9%的病例中观察到高凝状态(INR<0.9)和低凝状态(INR>1.2)，而在对照组中没有观察到(P<0.001)。此外，aPTT>40秒分别见于4.4%和4.7%的病例和对照,aPTT<30秒见于22%的病例,但未见于对照(P=0.004)。
■高血压和糖尿病是传统上与DVT无关的危险因素。除了完整的血细胞计数和凝血测试之外，这些还可以用于对我们人群和其他类似社区中的患者进行分层以进行预防。
■这是一项性别和年龄匹配的前瞻性病例对照研究，研究对象为45例多普勒证实的DVT和43例明显健康的对照。
■确定的危险因素包括高血压病史，糖尿病,以前的DVT,最近的手术,最近的创伤,恶性肿瘤，脓毒症,和不动。这些病例的平均血细胞比容显着降低（33±7.4％vs38±4.6％，p<0.001)。尽管在病例和对照组之间没有观察到白细胞和血小板计数的差异，但两组之间的白细胞增多与白细胞减少（P=0.003）和血小板增多与血小板减少（P=0.045）分层存在差异。此外，病例中国际标准化比率（INR）较高（1.1±0.2vs1.0±0.1；P=0.001），分别在4.4%和28.9%的病例中观察到高凝状态(INR<0.9)和低凝状态(INR>1.2)，而在对照组中没有观察到(P<0.001)。此外，aPTT>40秒分别见于4.4%和4.7%的病例和对照,aPTT<30秒见于22%的病例,但未见于对照(P=0.004)。
■高血压和糖尿病是传统上与DVT无关的危险因素。除了完整的血细胞计数和凝血测试之外，这些还可以用于对我们人群和其他类似社区中的患者进行分层以进行预防。
