PDF(Pubmed)
Abstract：
Atherosclerosis, a chronic disease associated with metabolism, poses a significant risk to human well-being. Currently, existing treatments for atherosclerosis lack sufficient efficiency, while the utilization of surface-modified nanoparticles holds the potential to deliver highly effective therapeutic outcomes. These nanoparticles can target and bind to specific receptors that are abnormally over-expressed in atherosclerotic conditions. This paper reviews recent research (2018-present) advances in various ligand-modified nanoparticle systems targeting atherosclerosis by specifically targeting signature molecules in the hope of precise treatment at the molecular level and concludes with a discussion of the challenges and prospects in this field. The intention of this review is to inspire novel concepts for the design and advancement of targeted nanomedicines tailored specifically for the treatment of atherosclerosis.
摘要：
动脉粥样硬化,一种与新陈代谢有关的慢性疾病，对人类福祉构成重大风险。目前,现有的治疗动脉粥样硬化缺乏足够的效率，而利用表面修饰的纳米颗粒具有提供高效治疗结果的潜力。这些纳米颗粒可以靶向并结合在动脉粥样硬化病症中异常过度表达的特异性受体。本文回顾了通过特异性靶向特征分子靶向动脉粥样硬化的各种配体修饰的纳米颗粒系统的最新研究进展（2018年至今），以期在分子水平上进行精确治疗，并最后讨论了该领域的挑战和前景。这篇综述的目的是为设计和发展专门为动脉粥样硬化治疗量身定制的靶向纳米药物提供新的概念。
