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Abstract：
Urologic oncology is a significant public health concern on a global scale. Recent research indicates that long chain non-coding RNAs (lncRNAs) and autophagy play crucial roles in various cancers, including urologic malignancies. This article provides a summary of the latest research findings, suggesting that lncRNA-mediated autophagy could either suppress or promote tumors in prostate, kidney, and bladder cancers. The intricate network involving different lncRNAs, target genes, and mediated signaling pathways plays a crucial role in urological malignancies by modulating the autophagic process. Dysregulated expression of lncRNAs can disrupt autophagy, leading to tumorigenesis, progression, and enhanced resistance to therapy. Consequently, targeting particular lncRNAs that control autophagy could serve as a dependable diagnostic tool and a promising prognostic biomarker in urologic oncology, while also holding potential as an effective therapeutic approach.
摘要：
泌尿外科肿瘤学在全球范围内是一个重要的公共卫生问题。最近的研究表明，长链非编码RNA（lncRNAs）和自噬在各种癌症中起着至关重要的作用。包括泌尿系恶性肿瘤.本文总结了最新的研究成果，表明lncRNA介导的自噬可以抑制或促进前列腺肿瘤，肾,和膀胱癌。涉及不同lncRNAs的复杂网络，靶基因,和介导的信号通路通过调节自噬过程在泌尿系恶性肿瘤中起着至关重要的作用。lncRNAs表达失调可以破坏自噬，导致肿瘤发生，programming,增强了对治疗的抵抗力。因此,靶向控制自噬的特定lncRNAs可以作为泌尿系肿瘤学中可靠的诊断工具和有前景的预后生物标志物,同时也具有作为有效治疗方法的潜力。
