PDF(Pubmed)
Abstract：
In computational models of reading, written words can be read using print-to-sound and/or print-to-meaning pathways. Neuroimaging data associate dorsal stream regions (left posterior occipitotemporal cortex, intraparietal cortex, dorsal inferior frontal gyrus [dIFG]) with the print-to-sound pathway and ventral stream regions (left anterior fusiform gyrus, middle temporal gyrus) with the print-to-meaning pathway. In 69 typical adults, we investigated whether resting state functional connectivity (RSFC) between the visual word form area (VWFA) and dorsal and ventral regions correlated with phonological (nonword reading, nonword repetition, spoonerisms), lexical-semantic (vocabulary, sensitivity to morpheme units in reading), and general literacy (word reading, spelling) skills. VWFA activity was temporally correlated with activity in both dorsal and ventral reading regions. In pre-registered whole-brain analyses, spoonerisms performance was positively correlated with RSFC between the VWFA and left dorsal regions (dIFG, superior parietal and intraparietal cortex). In exploratory region-of-interest analyses, VWFA-dIFG connectivity was also positively correlated with nonword repetition, spelling, and vocabulary. Connectivity between the VWFA and ventral stream regions was not associated with performance on any behavioural measure, either in whole-brain or region-of-interest analyses. Our results suggest that tasks such as spoonerisms and spellings, which are both complex (i.e., involve multiple subprocesses) and have high between-subject variability, provide greater opportunity for observing resting-state brain-behaviour associations. However, the complexity of these tasks limits the conclusions we can draw about the specific mechanisms that drive these associations. Future research would benefit from constructing latent variables from multiple tasks tapping the same reading subprocess.
摘要：
在阅读的计算模型中，可以使用打印到声音和/或打印到意义的途径阅读书面单词。神经影像学数据关联背侧血流区域(左后枕颞叶皮质，顶内皮质，背侧下额回[dIFG]），具有声纹到声音的通路和腹侧流区域（左前梭形回，颞中回）具有打印到意义的途径。在69个典型的成年人中，我们调查了视觉单词形式区域（VWFA）与背侧和腹侧区域之间的静息状态功能连接（RSFC）是否与语音相关（非单词阅读，非单词重复，spoonerisms),词汇语义(词汇，阅读中对语素单位的敏感性)，和一般识字(单词阅读，拼写)技能。VWFA活性与背侧和腹侧阅读区域的活性在时间上相关。在预先登记的全脑分析中，VWFA和左背侧区域之间的spoonerism表现与RSFC呈正相关(dIFG，上顶叶和顶内皮质）。在探索性感兴趣区域分析中，VWFA-dIFG连通性与非单词重复也呈正相关，拼写,和词汇。VWFA和腹侧流区域之间的连通性与任何行为测量的表现无关，无论是在全脑或感兴趣的区域分析。我们的结果表明，任务，如勺子和拼写，这两个都是复杂的(即，涉及多个子过程)，并且具有很高的主体间变异性，为观察静息状态的大脑行为关联提供了更大的机会。然而,这些任务的复杂性限制了我们可以得出的关于驱动这些关联的特定机制的结论。未来的研究将受益于从多个任务中利用相同的阅读子过程构建潜在变量。
