PDF(Pubmed)
Abstract：
UNASSIGNED: The purpose of this study was to evaluate the immunohistochemical effect of hyaluronic acid (HA) on the mineralization rate of the reparative dentin when it is used as a mixing medium with mineral trioxide aggregate (MTA).
UNASSIGNED: Direct pulp capping (DPC) was performed on 90 teeth from 10 dogs that had been experimentally exposed. The exposed pulps were divided into three groups according to the mixing medium with MTA: Group I: MTA + distilled water (control group), Group II: MTA + hybrid cooperative complex HA (HCC-HA), Group III: MTA + high molecular weight HA (HMW-HA). After pulp capping, all cavities were restored with final restoration. The dogs were divided randomly into five groups (two dogs each) according to the evaluation periods (7, 14, 21, 30, and 60) days. At the end of the study, the dogs were euthanized, and the sampled teeth were processed for immunohistochemical investigation.
UNASSIGNED: Both types of HA (HCC-HA, HMW-HA) showed an increase in the expression of alkaline phosphatase (ALP) at a higher rate than using distilled water with MTA.
UNASSIGNED: Within the limitations of this study, HA proved to be an effective additive to MTA for DPC.
UNASSIGNED: Direct pulp capping (DPC) was performed on 90 teeth from 10 dogs that had been experimentally exposed. The exposed pulps were divided into three groups according to the mixing medium with MTA: Group I: MTA + distilled water (control group), Group II: MTA + hybrid cooperative complex HA (HCC-HA), Group III: MTA + high molecular weight HA (HMW-HA). After pulp capping, all cavities were restored with final restoration. The dogs were divided randomly into five groups (two dogs each) according to the evaluation periods (7, 14, 21, 30, and 60) days. At the end of the study, the dogs were euthanized, and the sampled teeth were processed for immunohistochemical investigation.
UNASSIGNED: Both types of HA (HCC-HA, HMW-HA) showed an increase in the expression of alkaline phosphatase (ALP) at a higher rate than using distilled water with MTA.
UNASSIGNED: Within the limitations of this study, HA proved to be an effective additive to MTA for DPC.
摘要：
■这项研究的目的是评估透明质酸（HA）在用作具有矿物三氧化物聚集体（MTA）的混合介质时对修复性牙本质矿化速率的免疫组织化学作用。
■对10只已通过实验暴露的狗的90颗牙齿进行了直接盖髓（DPC）。根据具有MTA的混合介质将暴露的纸浆分为三组:第一组:MTA+蒸馏水(对照组),第二组：MTA+混合协同复合物HA（HCC-HA），组III:MTA+高分子量HA(HMW-HA)。盖浆后，所有的空洞都恢复了最后的修复。根据评估期(7、14、21、30和60天)将狗随机分为5组(每组2只狗)。在研究结束时,狗被安乐死,并对取样的牙齿进行免疫组化研究。
■两种类型的HA（HCC-HA，HMW-HA）显示碱性磷酸酶（ALP）表达的增加速率高于使用具有MTA的蒸馏水。
■在本研究的局限性内，HA被证明是用于DPC的MTA的有效添加剂。
■对10只已通过实验暴露的狗的90颗牙齿进行了直接盖髓（DPC）。根据具有MTA的混合介质将暴露的纸浆分为三组:第一组:MTA+蒸馏水(对照组),第二组：MTA+混合协同复合物HA（HCC-HA），组III:MTA+高分子量HA(HMW-HA)。盖浆后，所有的空洞都恢复了最后的修复。根据评估期(7、14、21、30和60天)将狗随机分为5组(每组2只狗)。在研究结束时,狗被安乐死,并对取样的牙齿进行免疫组化研究。
■两种类型的HA（HCC-HA，HMW-HA）显示碱性磷酸酶（ALP）表达的增加速率高于使用具有MTA的蒸馏水。
■在本研究的局限性内，HA被证明是用于DPC的MTA的有效添加剂。
