PDF(Pubmed)
Abstract：
UNASSIGNED: Previous studies have linked cardiovascular risk factors during midlife to cognitive function in later life. However, few studies have looked at the association between cardiac function, brain structure, and cognitive function and even less have included diverse middle-aged populations.
UNASSIGNED: The objective of this study was to determine associations between cardiac and brain structure and function in a multiethnic cohort of middle-aged adults.
UNASSIGNED: A cross-sectional study was conducted in participants of the Dallas Heart Study phase 2 (N = 1,919; 46% Black participants). Left ventricular (LV) mass, LV ejection fraction, LV concentricity, and peak systolic strain (LV Ecc) were assessed by cardiac magnetic resonance imaging. White matter hyperintensities (WMH) volume was measured by fluid attenuated inversion recovery magnetic resonance imaging. The Montreal Cognitive Assessment was used to measure cognitive functioning. Associations between cardiac and brain measures were determined using multivariable linear regression after adjusting for cardiovascular risk factors, education level, and physical activity.
UNASSIGNED: LV ejection fraction was associated with total Montreal Cognitive Assessment score (β = 0.06 [95% CI: 0.003-0.12], P = 0.042) and LV Ecc was associated with WMH volume (β = 0.08 [95% CI: 0.01-0.14], P = 0.025) in the overall cohort without significant interaction by race/ethnicity. Higher LV mass and concentricity were associated with larger WMH volume in the overall cohort (β = 0.13 [95% CI: 0.03-0.23], P = 0.008 and 0.10 [95% CI: 0.03-0.17], P = 0.005). These associations were more predominant in Black than White participants (β = 0.17 [95% CI: 0.04-0.30] vs β = -0.009 [95% CI: -0.16 to 0.14], P = 0.036 and β = 0.22 [95% CI: 0.13-0.32] vs β = -0.11 [95% CI: -0.21 to -0.01], P < 0.0001, for LV mass and concentricity, respectively).
UNASSIGNED: Subclinical cardiac dysfunction indicated by LVEF was associated with lower cognitive function. Moreover, LV mass and concentric remodeling were associated with higher WMH burden, particularly among Black individuals.
UNASSIGNED: The objective of this study was to determine associations between cardiac and brain structure and function in a multiethnic cohort of middle-aged adults.
UNASSIGNED: A cross-sectional study was conducted in participants of the Dallas Heart Study phase 2 (N = 1,919; 46% Black participants). Left ventricular (LV) mass, LV ejection fraction, LV concentricity, and peak systolic strain (LV Ecc) were assessed by cardiac magnetic resonance imaging. White matter hyperintensities (WMH) volume was measured by fluid attenuated inversion recovery magnetic resonance imaging. The Montreal Cognitive Assessment was used to measure cognitive functioning. Associations between cardiac and brain measures were determined using multivariable linear regression after adjusting for cardiovascular risk factors, education level, and physical activity.
UNASSIGNED: LV ejection fraction was associated with total Montreal Cognitive Assessment score (β = 0.06 [95% CI: 0.003-0.12], P = 0.042) and LV Ecc was associated with WMH volume (β = 0.08 [95% CI: 0.01-0.14], P = 0.025) in the overall cohort without significant interaction by race/ethnicity. Higher LV mass and concentricity were associated with larger WMH volume in the overall cohort (β = 0.13 [95% CI: 0.03-0.23], P = 0.008 and 0.10 [95% CI: 0.03-0.17], P = 0.005). These associations were more predominant in Black than White participants (β = 0.17 [95% CI: 0.04-0.30] vs β = -0.009 [95% CI: -0.16 to 0.14], P = 0.036 and β = 0.22 [95% CI: 0.13-0.32] vs β = -0.11 [95% CI: -0.21 to -0.01], P < 0.0001, for LV mass and concentricity, respectively).
UNASSIGNED: Subclinical cardiac dysfunction indicated by LVEF was associated with lower cognitive function. Moreover, LV mass and concentric remodeling were associated with higher WMH burden, particularly among Black individuals.
摘要：
■先前的研究将中年时期的心血管危险因素与晚年的认知功能联系起来。然而,很少有研究研究心脏功能之间的关系，大脑结构,和认知功能，甚至更少包括不同的中年人群。
■本研究的目的是确定中年人的多种族队列中心脏和大脑结构与功能之间的关联。
■在达拉斯心脏研究2期的参与者中进行了一项横断面研究（N=1,919；46％的黑人参与者）。左心室(LV)质量,左心室射血分数,LV同心度,和峰值收缩期应变（LVEcc）通过心脏磁共振成像进行评估。通过液体衰减反转恢复磁共振成像测量白质高强度（WMH）体积。蒙特利尔认知评估用于测量认知功能。在调整心血管危险因素后，使用多变量线性回归确定心脏和大脑测量之间的关联，教育水平,和身体活动。
■左心室射血分数与蒙特利尔认知评估总分相关（β=0.06[95％CI：0.003-0.12]，P=0.042）和LVEcc与WMH体积相关（β=0.08[95％CI：0.01-0.14]，P=0.025）在整个队列中，种族/种族没有显着相互作用。较高的左心室质量和同心度与整个队列中较大的WMH体积相关(β=0.13[95%CI:0.03-0.23],P=0.008和0.10[95%CI：0.03-0.17]，P=0.005)。这些关联在黑人中比白人参与者更占优势（β=0.17[95%CI：0.04-0.30]vsβ=-0.009[95%CI：-0.16至0.14]，P=0.036和β=0.22[95%CI：0.13-0.32]vsβ=-0.11[95%CI：-0.21至-0.01]，P<0.0001,对于LV质量和同心度,分别)。
■LVEF提示的亚临床心功能不全与认知功能降低相关。此外，左心室质量和同心重塑与较高的WMH负荷相关，尤其是黑人。
■本研究的目的是确定中年人的多种族队列中心脏和大脑结构与功能之间的关联。
■在达拉斯心脏研究2期的参与者中进行了一项横断面研究（N=1,919；46％的黑人参与者）。左心室(LV)质量,左心室射血分数,LV同心度,和峰值收缩期应变（LVEcc）通过心脏磁共振成像进行评估。通过液体衰减反转恢复磁共振成像测量白质高强度（WMH）体积。蒙特利尔认知评估用于测量认知功能。在调整心血管危险因素后，使用多变量线性回归确定心脏和大脑测量之间的关联，教育水平,和身体活动。
■左心室射血分数与蒙特利尔认知评估总分相关（β=0.06[95％CI：0.003-0.12]，P=0.042）和LVEcc与WMH体积相关（β=0.08[95％CI：0.01-0.14]，P=0.025）在整个队列中，种族/种族没有显着相互作用。较高的左心室质量和同心度与整个队列中较大的WMH体积相关(β=0.13[95%CI:0.03-0.23],P=0.008和0.10[95%CI：0.03-0.17]，P=0.005)。这些关联在黑人中比白人参与者更占优势（β=0.17[95%CI：0.04-0.30]vsβ=-0.009[95%CI：-0.16至0.14]，P=0.036和β=0.22[95%CI：0.13-0.32]vsβ=-0.11[95%CI：-0.21至-0.01]，P<0.0001,对于LV质量和同心度,分别)。
■LVEF提示的亚临床心功能不全与认知功能降低相关。此外，左心室质量和同心重塑与较高的WMH负荷相关，尤其是黑人。
