PDF(Pubmed)
Abstract：
UNASSIGNED: ZAP-X, a novel and dedicated radiosurgery (SRS) system, has recently emerged, while CyberKnife has solidified its position as a versatile solution for SRS and stereotactic body radiation therapy over the past two decades. This study aims to compare the dosimetric performance and delivery efficiency of ZAP-X and CyberKnife in treating brain metastases of varying target sizes, employing circular collimation.
UNASSIGNED: Twenty-three patients, encompassing a total of 47 brain metastases, were included in the creation of comparative plans of ZAP-X and CyberKnife for analysis. The comparative plans were generated to achieve identical prescription doses for the targets, while adhering to the same dose constraints for organs at risk (OAR). The prescription isodose percentage was optimized within the range of 97-100% for each plan to ensure effective target-volume coverage. To assess plan quality, indices such as conformity, homogeneity, and gradient (CI, HI, and GI) were computed, along with the reporting of total brain volumes receiving 12Gy and 10Gy. Estimated treatment time and monitor units (MUs) were compared between the two modalities in evaluating delivery efficiency.
UNASSIGNED: Overall, CyberKnife achieved better CI and HI, while ZAP-X exhibited better GI and a smaller irradiated volume for the normal brain. The superiority of CyberKnife\'s plan conformity was more pronounced for target size less than 1 cc and greater than 10 cc. Conversely, the advantage of ZAP-X\'s plan dose gradient was more notable for target sizes under 10 cc. The homogeneity of ZAP-X plans, employing multiple isocenters, displayed a strong correlation with the target\'s shape and the planner\'s experience in placing isocenters. Generally, the estimated treatment time was similar between the two modalities, and the delivery efficiency was significantly impacted by the chosen collimation sizes for both modalities.
UNASSIGNED: This study demonstrates that, within the range of target sizes within the patient cohort, plans generated by ZAP-X and CyberKnife exhibit comparable plan quality and delivery efficiency. At present, with the current platform of the two modalities, CyberKnife outperforms ZAP-X in terms of conformity and homogeneity, while ZAP-X tends to produce plans with a more rapid dose falloff.
UNASSIGNED: Twenty-three patients, encompassing a total of 47 brain metastases, were included in the creation of comparative plans of ZAP-X and CyberKnife for analysis. The comparative plans were generated to achieve identical prescription doses for the targets, while adhering to the same dose constraints for organs at risk (OAR). The prescription isodose percentage was optimized within the range of 97-100% for each plan to ensure effective target-volume coverage. To assess plan quality, indices such as conformity, homogeneity, and gradient (CI, HI, and GI) were computed, along with the reporting of total brain volumes receiving 12Gy and 10Gy. Estimated treatment time and monitor units (MUs) were compared between the two modalities in evaluating delivery efficiency.
UNASSIGNED: Overall, CyberKnife achieved better CI and HI, while ZAP-X exhibited better GI and a smaller irradiated volume for the normal brain. The superiority of CyberKnife\'s plan conformity was more pronounced for target size less than 1 cc and greater than 10 cc. Conversely, the advantage of ZAP-X\'s plan dose gradient was more notable for target sizes under 10 cc. The homogeneity of ZAP-X plans, employing multiple isocenters, displayed a strong correlation with the target\'s shape and the planner\'s experience in placing isocenters. Generally, the estimated treatment time was similar between the two modalities, and the delivery efficiency was significantly impacted by the chosen collimation sizes for both modalities.
UNASSIGNED: This study demonstrates that, within the range of target sizes within the patient cohort, plans generated by ZAP-X and CyberKnife exhibit comparable plan quality and delivery efficiency. At present, with the current platform of the two modalities, CyberKnife outperforms ZAP-X in terms of conformity and homogeneity, while ZAP-X tends to produce plans with a more rapid dose falloff.
摘要：
■ZAP-X,一种新颖的专用放射外科（SRS）系统，最近出现了，在过去的二十年中，Cyberknife巩固了其作为SRS和立体定向身体放射治疗的通用解决方案的地位。本研究旨在比较ZAP-X和射波刀治疗不同靶点大小的脑转移瘤的剂量学性能和递送效率。采用圆形准直。
■23名患者，总共包括47个脑转移瘤，包括在ZAP-X和CyberKnife的比较计划的创建中进行分析。生成比较计划以实现相同的目标处方剂量，同时对危险器官（OAR）坚持相同的剂量限制。每个计划的处方等剂量百分比在97-100％的范围内进行优化，以确保有效的目标体积覆盖率。要评估计划质量，一致性等指标，同质性，和梯度(CI，HI，和GI)进行了计算，以及接收12Gy和10Gy的大脑总体积的报告。在评估分娩效率时，比较了两种模式之间估计的治疗时间和监测单位（MU）。
■总的来说，射波刀取得了更好的CI和HI，而ZAP-X对正常大脑表现出更好的GI和更小的照射体积。对于小于1cc和大于10cc的目标尺寸，赛波刀计划一致性的优越性更为明显。相反，ZAP-X计划剂量梯度的优势在10cc以下的靶大小更显著。ZAP-X计划的同质性，雇佣多个等中心，显示与目标的形状和计划者在放置等中心方面的经验有很强的相关性。一般来说,两种模式的估计治疗时间相似，并且递送效率受到两种模式的选择的准直尺寸的显著影响。
■这项研究表明，在患者队列中的目标大小范围内，ZAP-X和CyberKnife生成的计划具有可比的计划质量和交付效率。目前,在两种模式的当前平台下，Cyberknife在一致性和同质性方面优于ZAP-X，而ZAP-X倾向于产生剂量下降更快的计划。
■23名患者，总共包括47个脑转移瘤，包括在ZAP-X和CyberKnife的比较计划的创建中进行分析。生成比较计划以实现相同的目标处方剂量，同时对危险器官（OAR）坚持相同的剂量限制。每个计划的处方等剂量百分比在97-100％的范围内进行优化，以确保有效的目标体积覆盖率。要评估计划质量，一致性等指标，同质性，和梯度(CI，HI，和GI)进行了计算，以及接收12Gy和10Gy的大脑总体积的报告。在评估分娩效率时，比较了两种模式之间估计的治疗时间和监测单位（MU）。
■总的来说，射波刀取得了更好的CI和HI，而ZAP-X对正常大脑表现出更好的GI和更小的照射体积。对于小于1cc和大于10cc的目标尺寸，赛波刀计划一致性的优越性更为明显。相反，ZAP-X计划剂量梯度的优势在10cc以下的靶大小更显著。ZAP-X计划的同质性，雇佣多个等中心，显示与目标的形状和计划者在放置等中心方面的经验有很强的相关性。一般来说,两种模式的估计治疗时间相似，并且递送效率受到两种模式的选择的准直尺寸的显著影响。
■这项研究表明，在患者队列中的目标大小范围内，ZAP-X和CyberKnife生成的计划具有可比的计划质量和交付效率。目前,在两种模式的当前平台下，Cyberknife在一致性和同质性方面优于ZAP-X，而ZAP-X倾向于产生剂量下降更快的计划。
