PDF(Pubmed)
Abstract：
Triiodothyronine (T3) concentrations in plasma decrease during acute illness and it is unclear if this contributes to disease. Clinical and laboratory studies of T3 supplementation in disease have revealed little or no effect. It is uncertain if short term supplementation of T3 has any discernible effect in a healthy animals. Observational study of intravenous T3 (1 µg/kg/h) for 24 h in a healthy sheep model receiving protocol-guided intensive care supports (T3 group, n=5). A total of 45 endpoints were measured including hemodynamic, respiratory, renal, hematological, metabolic and endocrine parameters. Data were compared with previously published studies of sheep subject to the same support protocol without administered T3 (No T3 group, n=5). Plasma free T3 concentrations were elevated 8-fold by the infusion (pmol/l at 24 h; T3 group 34.9±9.9 vs. No T3 group 4.4±0.3, P<0.01, reference range 1.6 to 6.8). There was no significant physiological response to administration of T3 over the study duration. Supplementation of intravenous T3 for 24 h has no physiological effect on relevant physiological endpoints in healthy sheep. Further research is required to understand if the lack of effect of short-term T3 may be related to kinetics of T3 cellular uptake, metabolism and action, or acute counterbalancing hormone resistance. This information may be helpful in design of clinical T3 supplementation trials.
摘要：
急性疾病期间血浆中的三碘甲状腺原氨酸（T3）浓度降低，目前尚不清楚这是否会导致疾病。疾病中补充T3的临床和实验室研究显示效果很小或没有效果。不确定短期补充T3在健康动物中是否具有任何可辨别的效果。在接受方案指导的重症监护支持的健康绵羊模型中，静脉注射T3（1µg/kg/h）24小时的观察性研究（T3组，n=5)。总共测量了45个终点，包括血液动力学，呼吸,肾,血液学,代谢和内分泌参数。将数据与先前发表的对接受相同支持方案但未施用T3的绵羊的研究进行比较（无T3组，n=5)。输注后血浆游离T3浓度升高了8倍（24小时pmol/l；T3组34.9±9.9vs.无T3组4.4±0.3,P<0.01,参考范围1.6～6.8)。在研究持续时间内,对T3的施用没有显著的生理反应。补充24小时的静脉注射T3对健康绵羊的相关生理终点没有生理影响。需要进一步的研究来了解短期T3的缺乏可能与T3细胞摄取的动力学有关。新陈代谢和行动，或急性平衡激素抵抗。这些信息可能有助于设计临床T3补充试验。
