PDF(Pubmed)
Abstract：
Cancer stands as a significant contributor to global mortality rates, primarily driven by its progression and widespread dissemination. Despite notable strides in cancer therapy, the efficacy of current treatment strategies is compromised due to their inherent toxicity and the emergence of chemoresistance. Consequently, there is a critical need to evaluate alternative therapeutic approaches, with natural compounds emerging as promising candidates, showcasing demonstrated anticancer capabilities in various research models. This review manuscript presents a comprehensive examination of the regulatory mechanisms governing the expression of matrix metalloproteinases (MMPs) and delves into the potential therapeutic role of flavonoids as agents exhibiting specific anticancer activity against MMPs. The primary aim of this study is to elucidate the diverse functions associated with MMP production in cancer and to investigate the potential of flavonoids in modulating MMP expression to inhibit metastasis.
摘要：
癌症是全球死亡率的重要因素，主要是由它的进步和广泛传播驱动的。尽管癌症治疗取得了显著进展，当前治疗策略的疗效由于其固有毒性和化疗耐药的出现而受到影响.因此,迫切需要评估替代治疗方法，随着天然化合物成为有希望的候选者，展示了在各种研究模型中展示的抗癌能力。这篇综述手稿对控制基质金属蛋白酶（MMPs）表达的调节机制进行了全面的研究，并探讨了黄酮类化合物作为对MMPs具有特定抗癌活性的药物的潜在治疗作用。这项研究的主要目的是阐明与癌症中MMP产生相关的多种功能，并研究类黄酮在调节MMP表达以抑制转移方面的潜力。
