PDF(Pubmed)
Abstract：
UNASSIGNED: Coarctation of the aorta (CoA) is associated with intracranial aneurysms (IAs); however, the prevalence and risk factors (RFs) are not well described. Current practice guidelines offer inconsistent recommendations on screening for IAs in this patient population ranging from \"not recommended\" (European Society of Cardiology 2020) to \"recommended\" (American Heart Association 2018).
UNASSIGNED: The purpose of this study was to determine the prevalence and RFs for IAs in patients with CoA.
UNASSIGNED: We completed a systematic review and meta-analysis of studies utilizing computed tomography or magnetic resonance angiographic screening for IAs in patients with CoA.
UNASSIGNED: Five cohort studies were included, representing 442 patients. The pooled prevalence of IAs in patients with CoA was 3.8% [95% CI: 0.1%-12.3%]. The results met our prespecified definition for high heterogeneity. Of 5 RFs evaluated, only hypertension was associated with the development of IAs with an odds ratio of 3.1 [95% CI: 1.1-8.2; P = 0.03]. There was an observed downward trend over time in the prevalence of IAs among the studies included.
UNASSIGNED: The development of IAs is likely multifactorial in etiology and there may be modifiable RFs in their development. Considering the low prevalence of IAs in the pooled result, routine screening of patients with CoA for IAs is likely of low-value.
UNASSIGNED: The purpose of this study was to determine the prevalence and RFs for IAs in patients with CoA.
UNASSIGNED: We completed a systematic review and meta-analysis of studies utilizing computed tomography or magnetic resonance angiographic screening for IAs in patients with CoA.
UNASSIGNED: Five cohort studies were included, representing 442 patients. The pooled prevalence of IAs in patients with CoA was 3.8% [95% CI: 0.1%-12.3%]. The results met our prespecified definition for high heterogeneity. Of 5 RFs evaluated, only hypertension was associated with the development of IAs with an odds ratio of 3.1 [95% CI: 1.1-8.2; P = 0.03]. There was an observed downward trend over time in the prevalence of IAs among the studies included.
UNASSIGNED: The development of IAs is likely multifactorial in etiology and there may be modifiable RFs in their development. Considering the low prevalence of IAs in the pooled result, routine screening of patients with CoA for IAs is likely of low-value.
摘要：
■主动脉缩窄（CoA）与颅内动脉瘤（IAs）有关；然而，患病率和危险因素（RFs）没有很好的描述。当前的实践指南对该患者人群中的IAs筛查提供了不一致的建议，范围从“不推荐”（欧洲心脏病学会2020年）到“推荐”（美国心脏协会2018年）。
■这项研究的目的是确定CoA患者中IAs的患病率和RF。
■我们利用计算机断层扫描或磁共振血管造影筛查CoA患者的IAs，对研究进行了系统评价和荟萃分析。
■纳入了五项队列研究，代表442名患者。CoA患者中IAs的合并患病率为3.8%[95%CI:0.1%-12.3%]。结果符合我们对高异质性的预定定义。在评估的5个RF中，只有高血压与IAs的发展相关,比值比为3.1[95%CI:1.1-8.2;P=0.03].在纳入的研究中，随着时间的推移，IAs的患病率呈下降趋势。
■IAs的发展在病因上可能是多因素的，并且在其发展中可能存在可修改的RF。考虑到IAs在汇总结果中的患病率较低，对CoA患者进行IAs常规筛查的价值可能较低。
■这项研究的目的是确定CoA患者中IAs的患病率和RF。
■我们利用计算机断层扫描或磁共振血管造影筛查CoA患者的IAs，对研究进行了系统评价和荟萃分析。
■纳入了五项队列研究，代表442名患者。CoA患者中IAs的合并患病率为3.8%[95%CI:0.1%-12.3%]。结果符合我们对高异质性的预定定义。在评估的5个RF中，只有高血压与IAs的发展相关,比值比为3.1[95%CI:1.1-8.2;P=0.03].在纳入的研究中，随着时间的推移，IAs的患病率呈下降趋势。
■IAs的发展在病因上可能是多因素的，并且在其发展中可能存在可修改的RF。考虑到IAs在汇总结果中的患病率较低，对CoA患者进行IAs常规筛查的价值可能较低。
