PDF(Pubmed)
Abstract：
BACKGROUND: Maternal smoking during pregnancy disturbs fetal lung development, and induces in their offspring childhood respiratory diseases. Whether it has a continued impact on offspring adult lung health and exerts a casual effect of chronic respiratory diseases (CRDs), remains uncertain. We seek to determine the causal relationships between maternal smoking around birth and offspring adult CRDs, using summary data from previously described cohorts.
METHODS: Mendelian randomization (MR) study was used to analyze the genome-wide associations of maternal smoking around birth and offspring adult CRDs, including respiratory insufficiency, chronic obstructive pulmonary disease (COPD), related respiratory insufficiency, emphysema, COPD, COPD hospital admissions, early onset of COPD, later onset of COPD, asthma, idiopathic pulmonary fibrosis (IPF), lung cancer (LC), small cell lung carcinoma (SCLC), and lung squamous cell carcinoma (LUSC).
RESULTS: After removing single-nucleotide polymorphisms (SNPs) associated with smoking by the offspring, maternal smoking around birth was associated with increased risk of offspring adult respiratory diseases (OR=1.14; 95% CI: 1.013-1.284; p=0.030), respiratory insufficiency (OR=2.413; 95% CI: 1.039-5.603; p=0.040), COPD (OR=1.14; 95% CI: 1.013-1.284; p=0.003), and asthma (OR=1.336; 95% CI: 1.161-1.538; p<0.001). Besides, maternal smoking during pregnancy was associated with a greater risk of LUSC (OR=1.229; 95% CI: 0.992-1.523; p=0.059) than the risk of IPF (OR=1.001; 95% CI: 0.999-1.003; p=0.224), LC (OR=1.203; 95% CI: 0.964-1.501; p=0.103), or SCLC (OR=1.11; 95% CI: 0.77-1.601; p=0.577).
CONCLUSIONS: In this MR analysis, maternal smoking around birth caused a strong risk factor for the offspring to develop lung problems and CRDs in adulthood. The policy related to smoking cessation for mothers during pregnancy should be encouraged.
METHODS: Mendelian randomization (MR) study was used to analyze the genome-wide associations of maternal smoking around birth and offspring adult CRDs, including respiratory insufficiency, chronic obstructive pulmonary disease (COPD), related respiratory insufficiency, emphysema, COPD, COPD hospital admissions, early onset of COPD, later onset of COPD, asthma, idiopathic pulmonary fibrosis (IPF), lung cancer (LC), small cell lung carcinoma (SCLC), and lung squamous cell carcinoma (LUSC).
RESULTS: After removing single-nucleotide polymorphisms (SNPs) associated with smoking by the offspring, maternal smoking around birth was associated with increased risk of offspring adult respiratory diseases (OR=1.14; 95% CI: 1.013-1.284; p=0.030), respiratory insufficiency (OR=2.413; 95% CI: 1.039-5.603; p=0.040), COPD (OR=1.14; 95% CI: 1.013-1.284; p=0.003), and asthma (OR=1.336; 95% CI: 1.161-1.538; p<0.001). Besides, maternal smoking during pregnancy was associated with a greater risk of LUSC (OR=1.229; 95% CI: 0.992-1.523; p=0.059) than the risk of IPF (OR=1.001; 95% CI: 0.999-1.003; p=0.224), LC (OR=1.203; 95% CI: 0.964-1.501; p=0.103), or SCLC (OR=1.11; 95% CI: 0.77-1.601; p=0.577).
CONCLUSIONS: In this MR analysis, maternal smoking around birth caused a strong risk factor for the offspring to develop lung problems and CRDs in adulthood. The policy related to smoking cessation for mothers during pregnancy should be encouraged.
摘要：
背景：孕妇在怀孕期间吸烟会扰乱胎儿肺部发育，并在他们的后代中诱发儿童呼吸道疾病。它是否对后代成人肺部健康产生持续影响，并对慢性呼吸系统疾病（CRDs）产生偶然影响，仍然不确定。我们试图确定出生前后母亲吸烟与后代成人CRDs之间的因果关系，使用来自先前描述的队列的汇总数据。
方法：孟德尔随机化（MR）研究用于分析出生前后母亲吸烟和后代成人CRDs的全基因组关联，包括呼吸功能不全,慢性阻塞性肺疾病(COPD),相关呼吸功能不全,肺气肿,COPD,COPD住院，COPD的早期发作，COPD的晚期发作，哮喘,特发性肺纤维化（IPF），肺癌（LC），小细胞肺癌（SCLC），肺鳞状细胞癌（LUSC）。
结果：在去除与后代吸烟相关的单核苷酸多态性（SNPs）后，母亲出生前后吸烟与后代成人呼吸系统疾病风险增加相关(OR=1.14;95%CI:1.013-1.284;p=0.030),呼吸功能不全（OR=2.413；95%CI：1.039-5.603；p=0.040），COPD（OR=1.14；95%CI：1.013-1.284；p=0.003），和哮喘（OR=1.336；95%CI：1.161-1.538；p<0.001）。此外,孕妇在怀孕期间吸烟与LUSC的风险(OR=1.229;95%CI:0.992-1.523;p=0.059)高于IPF的风险(OR=1.001;95%CI:0.999-1.003;p=0.224),LC（OR=1.203；95%CI：0.964-1.501；p=0.103），或SCLC（OR=1.11；95%CI：0.77-1.601；p=0.577）。
结论：在此MR分析中，母亲在出生时吸烟会导致后代在成年期出现肺部问题和CRDs。应鼓励有关怀孕期间母亲戒烟的政策。
方法：孟德尔随机化（MR）研究用于分析出生前后母亲吸烟和后代成人CRDs的全基因组关联，包括呼吸功能不全,慢性阻塞性肺疾病(COPD),相关呼吸功能不全,肺气肿,COPD,COPD住院，COPD的早期发作，COPD的晚期发作，哮喘,特发性肺纤维化（IPF），肺癌（LC），小细胞肺癌（SCLC），肺鳞状细胞癌（LUSC）。
结果：在去除与后代吸烟相关的单核苷酸多态性（SNPs）后，母亲出生前后吸烟与后代成人呼吸系统疾病风险增加相关(OR=1.14;95%CI:1.013-1.284;p=0.030),呼吸功能不全（OR=2.413；95%CI：1.039-5.603；p=0.040），COPD（OR=1.14；95%CI：1.013-1.284；p=0.003），和哮喘（OR=1.336；95%CI：1.161-1.538；p<0.001）。此外,孕妇在怀孕期间吸烟与LUSC的风险(OR=1.229;95%CI:0.992-1.523;p=0.059)高于IPF的风险(OR=1.001;95%CI:0.999-1.003;p=0.224),LC（OR=1.203；95%CI：0.964-1.501；p=0.103），或SCLC（OR=1.11；95%CI：0.77-1.601；p=0.577）。
结论：在此MR分析中，母亲在出生时吸烟会导致后代在成年期出现肺部问题和CRDs。应鼓励有关怀孕期间母亲戒烟的政策。
