UNASSIGNED: This multicenter retrospective observational study analyzed patients with AIS treated with intravenous r-tPA. sICH was defined as a worsening of 4 or higher points in the National Institutes of Health Stroke Scale (NIHSS) score within 36 hours after intravenous thrombolysis in any hemorrhage subtype. We assessed the odds ratio (OR) with 95% confidence interval (CI) of lipid profile for sICH for each sex using logistic regression models adjusted for potential confounding factors.
UNASSIGNED: Of 957 participants (median age 68 (interquartile range, 59-75), men 628 (65.6%)), 56 sICH events (36 (5.7%) in men and 20 (6.1%) in women) were observed. The risk of sICH in men decreased with increasing serum levels of triglyceride after adjustment for confounding factors (vs lowest tertile, medium tertile OR 0.39, 95% CI [0.17-0.91], top tertile OR 0.33, 95% CI [0.13-0.84], overall p = 0.021; per point increase, adjusted OR 0.29, 95% CI [0.13-0.63], p = 0.002). Neither serum levels of total cholesterol nor low-density lipoprotein (LDL) was associated with sICH in men. In women, there was no association between any of the lipid levels and the risk of sICH.
UNASSIGNED: This study indicated that the association between serum levels of triglyceride and sICH may vary by sex. In men, increased triglyceride levels decrease the risk of sICH; in women, this association was lost. Further studies on the biological mechanisms for sex differences in stroke risk associated with triglyceride are needed.
■这项多中心回顾性观察性研究分析了静脉r-tPA治疗的AIS患者。sICH定义为任何出血亚型在静脉溶栓后36小时内美国国立卫生研究院卒中量表(NIHSS)评分恶化4分或更高.我们使用逻辑回归模型对潜在的混杂因素进行了校正,评估了每种性别的sICH血脂谱的比值比(OR)和95%置信区间(CI)。
■957名参与者(平均年龄68岁(四分位距,59-75),男性628人(65.6%),观察到56例sICH事件(男性36例(5.7%),女性20例(6.1%))。在校正混杂因素后,随着血清甘油三酯水平的升高,男性sICH的风险降低(与最低三元组相比,中等三分位数或0.39,95%CI[0.17-0.91],最高三分位数或0.33,95%CI[0.13-0.84],总体p=0.021;每增加一个点,调整后OR0.29,95%CI[0.13-0.63],p=0.002)。男性血清总胆固醇和低密度脂蛋白(LDL)水平均与sICH无关。在女性中,任何血脂水平与sICH风险之间均无关联.
■这项研究表明,血清甘油三酯水平与sICH之间的关联可能因性别而异。在男人中,甘油三酯水平升高降低sICH的风险;在女性中,这个协会已经失去了。需要进一步研究与甘油三酯相关的卒中风险性别差异的生物学机制。