PDF(Pubmed)
Abstract：
Blood cell-derived extracellular vesicles (BCEVs) and lipoproteins are the major circulating nanoparticles in blood that play an important role in intercellular communication. They have attracted significant interest for clinical applications, given their endogenous characteristics which make them stable, biocompatible, well tolerated, and capable of permeating biological barriers efficiently. In this review, we describe the basic characteristics of BCEVs and lipoproteins and summarize their implications in both physiological and pathological processes. We also outline well accepted workflows for the isolation and characterization of these circulating nanoparticles. Importantly, we highlight the latest progress and challenges associated with the use of circulating nanoparticles as diagnostic biomarkers and therapeutic interventions in multiple diseases. We spotlight novel engineering approaches and designs to facilitate the development of these nanoparticles by enhancing their stability, targeting capability, and delivery efficiency. Therefore, the present work provides a comprehensive overview of composition, biogenesis, functions, and clinical translation of circulating nanoparticles from the bench to the bedside.
摘要：
血细胞来源的细胞外囊泡（BCEV）和脂蛋白是血液中主要的循环纳米颗粒，在细胞间通讯中起重要作用。它们在临床应用中引起了极大的兴趣，鉴于它们的内生特性使它们稳定，生物相容性良好的耐受性，并且能够有效地渗透生物屏障。在这次审查中,我们描述了BCEVs和脂蛋白的基本特征，并总结了它们在生理和病理过程中的意义。我们还概述了这些循环纳米颗粒的分离和表征的公认工作流程。重要的是,我们重点介绍了循环纳米颗粒作为多种疾病诊断生物标志物和治疗干预措施的最新进展和挑战.我们聚焦新的工程方法和设计，通过增强它们的稳定性来促进这些纳米粒子的发展，瞄准能力，和交付效率。因此,本工作提供了组成的全面概述，生物发生，功能,以及循环纳米颗粒从工作台到床边的临床翻译。
