PDF(Pubmed)
Abstract：
UNASSIGNED: Acute hemorrhage is fatal in equines with a complication of severe hypovolemic shock that causes a sudden death in such cases.
UNASSIGNED: This study was designed to report the influences of acute bleeding in conscious non-sedated donkeys (Equus asinus) on the hematobiochemical variables, acid-base, blood gas elements, and markers of inflammation and bone metabolism.
UNASSIGNED: Eight healthy donkeys were used where a total of 900 ml of whole blood was collected. Five blood samples were collected from each animal: just before collection of blood (T0); (2) 30 (T1), 60 (T2), 120 (T3), and 240 minutes (T4) later. The blood panels including total white blood cells, lymphocytes, neutrophils, red blood cell counts (RBCs), HCT, hemoglobin (Hg), and RBCs indices were measured. Biochemical parameters and electrolytes were evaluated. The activity of aspartate aminotransferase (AST), creatine kinase (CK), and γ-glutamyl transferase (GGT) were also determined. Complete acid-base and blood gas panels were assessed. Serum amyloid A (SAA), haptoglobin (Hp), osteocalcin (OC), bone alkaline phosphatase (b-ALP), and pyridinoline cross-links (PYD) were measured.
UNASSIGNED: The RBCs, Hg, and HCT increased significantly at points T1, T2, and T3 compared to T0. The concentrations of total proteins and albumin decreased significantly at points T3 and T4. The blood urea nitrogen concentrations increased significantly at T4. Creatinine concentrations increased significantly at T2 and T3. The AST, GGT, and CK decreased significantly. On the other hand, glucose increased significantly at T3 and T4. The pH decreased significantly at points T1, T2, T3, and T4. The PCO2 increased significantly at T3 and T4. The BE, HCO3, and TCO2 values decreased significantly at T2, T3, and T4. Contrary, the AG increased significantly at points T3 and T4. The potassium increased significantly at T1-T4 and chloride decreased significantly at T3 and T4. Lactate showed significant increases at T1-T4. The SAA, Hp, OC, b-ALP, and PYD did not differ significantly at T1-T4.
UNASSIGNED: In conscious non-sedated donkeys, induced bleeding resulted in significant changes in the hematobiochemical elements, the acid-base status, and blood gas and electrolyte parameters. However, it did not change the markers of inflammation and bone metabolism.
UNASSIGNED: This study was designed to report the influences of acute bleeding in conscious non-sedated donkeys (Equus asinus) on the hematobiochemical variables, acid-base, blood gas elements, and markers of inflammation and bone metabolism.
UNASSIGNED: Eight healthy donkeys were used where a total of 900 ml of whole blood was collected. Five blood samples were collected from each animal: just before collection of blood (T0); (2) 30 (T1), 60 (T2), 120 (T3), and 240 minutes (T4) later. The blood panels including total white blood cells, lymphocytes, neutrophils, red blood cell counts (RBCs), HCT, hemoglobin (Hg), and RBCs indices were measured. Biochemical parameters and electrolytes were evaluated. The activity of aspartate aminotransferase (AST), creatine kinase (CK), and γ-glutamyl transferase (GGT) were also determined. Complete acid-base and blood gas panels were assessed. Serum amyloid A (SAA), haptoglobin (Hp), osteocalcin (OC), bone alkaline phosphatase (b-ALP), and pyridinoline cross-links (PYD) were measured.
UNASSIGNED: The RBCs, Hg, and HCT increased significantly at points T1, T2, and T3 compared to T0. The concentrations of total proteins and albumin decreased significantly at points T3 and T4. The blood urea nitrogen concentrations increased significantly at T4. Creatinine concentrations increased significantly at T2 and T3. The AST, GGT, and CK decreased significantly. On the other hand, glucose increased significantly at T3 and T4. The pH decreased significantly at points T1, T2, T3, and T4. The PCO2 increased significantly at T3 and T4. The BE, HCO3, and TCO2 values decreased significantly at T2, T3, and T4. Contrary, the AG increased significantly at points T3 and T4. The potassium increased significantly at T1-T4 and chloride decreased significantly at T3 and T4. Lactate showed significant increases at T1-T4. The SAA, Hp, OC, b-ALP, and PYD did not differ significantly at T1-T4.
UNASSIGNED: In conscious non-sedated donkeys, induced bleeding resulted in significant changes in the hematobiochemical elements, the acid-base status, and blood gas and electrolyte parameters. However, it did not change the markers of inflammation and bone metabolism.
摘要：
■急性出血在马科动物中是致命的，伴有严重低血容量性休克的并发症，在这种情况下会导致猝死。
■本研究旨在报告有意识的非镇静驴（马）急性出血对血液生化变量的影响，酸碱，血气元素,炎症和骨代谢的标志物。
■使用八只健康的驴,其中收集总共900ml的全血。从每只动物收集五个血样:就在收集血液之前(T0);(2)30(T1),60(T2),120(T3),240分钟（T4）后。包括白细胞总数在内的血块,淋巴细胞，中性粒细胞，红细胞计数（RBC），HCT,血红蛋白（Hg），并测量红细胞指数。评价生化参数和电解质。天冬氨酸氨基转移酶（AST）的活性，肌酸激酶（CK），还测定了γ-谷氨酰转移酶(GGT)。评估完整的酸碱和血气面板。血清淀粉样蛋白A(SAA),触珠蛋白（Hp），骨钙蛋白（OC），骨碱性磷酸酶(b-ALP),并测定吡啶啉交联(PYD)。
■红细胞，Hg,与T0相比，在T1，T2和T3点HCT显着增加。总蛋白和白蛋白的浓度在T3和T4点显著降低。在T4时，血液尿素氮浓度显着增加。肌酐浓度在T2和T3时显著增加。AST,GGT,CK显著下降。另一方面,葡萄糖在T3和T4时显著增加。pH在点T1、T2、T3和T4处显著降低。PCO2在T3和T4时显著增加。TheBE,HCO3和TCO2值在T2、T3和T4时显著降低。相反，AG在T3和T4点显著增加。在T1-T4时钾显着增加，在T3和T4时氯显着降低。乳酸在T1-T4显示显著增加。SAA,HP,OC,b-ALP,和PYD在T1-T4没有显著差异。
■在有意识的非镇静驴中，诱导出血导致血液生物化学元素的显著变化，酸碱状态，以及血气和电解质参数。然而,它没有改变炎症和骨代谢的标志物。
■本研究旨在报告有意识的非镇静驴（马）急性出血对血液生化变量的影响，酸碱，血气元素,炎症和骨代谢的标志物。
■使用八只健康的驴,其中收集总共900ml的全血。从每只动物收集五个血样:就在收集血液之前(T0);(2)30(T1),60(T2),120(T3),240分钟（T4）后。包括白细胞总数在内的血块,淋巴细胞，中性粒细胞，红细胞计数（RBC），HCT,血红蛋白（Hg），并测量红细胞指数。评价生化参数和电解质。天冬氨酸氨基转移酶（AST）的活性，肌酸激酶（CK），还测定了γ-谷氨酰转移酶(GGT)。评估完整的酸碱和血气面板。血清淀粉样蛋白A(SAA),触珠蛋白（Hp），骨钙蛋白（OC），骨碱性磷酸酶(b-ALP),并测定吡啶啉交联(PYD)。
■红细胞，Hg,与T0相比，在T1，T2和T3点HCT显着增加。总蛋白和白蛋白的浓度在T3和T4点显著降低。在T4时，血液尿素氮浓度显着增加。肌酐浓度在T2和T3时显著增加。AST,GGT,CK显著下降。另一方面,葡萄糖在T3和T4时显著增加。pH在点T1、T2、T3和T4处显著降低。PCO2在T3和T4时显著增加。TheBE,HCO3和TCO2值在T2、T3和T4时显著降低。相反，AG在T3和T4点显著增加。在T1-T4时钾显着增加，在T3和T4时氯显着降低。乳酸在T1-T4显示显著增加。SAA,HP,OC,b-ALP,和PYD在T1-T4没有显著差异。
■在有意识的非镇静驴中，诱导出血导致血液生物化学元素的显著变化，酸碱状态，以及血气和电解质参数。然而,它没有改变炎症和骨代谢的标志物。
