PDF(Pubmed)
Abstract：
Cellular communication is essential for effective coordination of biological processes. One major form of intercellular communication occurs via the release of extracellular vesicles (EVs). These vesicles mediate intercellular communication through the transfer of their cargo and are actively explored for their role in various diseases and their potential therapeutic and diagnostic applications. Conversely, lipid droplets (LDs) are vesicles that transfer cargo within cells. Lipid droplets play roles in various diseases and evidence for their ability to transfer cargo between cells is emerging. To date, there has been little interdisciplinary research looking at the similarities and interactions between these two classes of small lipid vesicles. This review will compare the commonalities and differences between EVs and LDs including their biogenesis and secretion, isolation and characterisation methodologies, composition, and general heterogeneity and discuss challenges and opportunities in both fields.
摘要：
细胞通讯对于有效协调生物过程至关重要。细胞间通讯的一种主要形式通过细胞外囊泡(EV)的释放发生。这些囊泡通过其货物的转移来介导细胞间的通讯，并积极探索其在各种疾病中的作用及其潜在的治疗和诊断应用。相反，脂滴（LD）是在细胞内转移货物的囊泡。脂滴在各种疾病中发挥作用，并且正在出现它们在细胞之间转移货物的能力的证据。迄今为止,很少有跨学科研究研究这两类小的脂质囊泡之间的相似性和相互作用。这篇综述将比较EV和LD之间的共性和差异，包括它们的生物发生和分泌，隔离和表征方法，composition,和一般异质性，并讨论这两个领域的挑战和机遇。
