PDF(Pubmed)
Abstract：
UNASSIGNED: Congenital heart disease (CHD) affects 8 in 1,000 live births with significant postnatal implications including growth failure, neurodevelopmental delay, and mortality. The placenta develops concomitantly with the fetal heart. High rates of placental pathology and discordant growth in pregnancies affected by CHD highlight the significance of the fetal-placental-cardiac axis.
UNASSIGNED: This study aimed to characterize the relationship between neonatal birthweight (BW), head circumference, placental weight (PW), and placental pathology in pregnancies affected by CHD. PW:BW provides a surrogate to assess placental efficiency, or nutrient exchange and delivery by the placenta, across CHD phenotypes.
UNASSIGNED: Retrospective cohort of 139 live-born singletons with postnatally confirmed CHD with placental pathology. Placental examination, infant BW, head circumference, and CHD categories (septal defects, right-sided defects, left-sided defects, conotruncal anomalies, and others) were included. Chi-square, Fisher\'s exact, or Kruskall-Wallis tests and multinomial logistic regressions, as appropriate.
UNASSIGNED: Median birthweight and head circumference percentile was 33 and 35, respectively. Placental pathology was documented in 37% of cases. PW to BW ratios were <10th percentile for 78% and <3rd percentile for 54% of the cohort, with no difference between CHD categories (P = 0.39 and P = 0.56, respectively).
UNASSIGNED: Infants with CHD have preserved BW and head circumferences in the setting of small placentas and increased prevalence of placental pathology, suggesting placental efficiency. Detection of abnormal placental growth could add prenatal diagnostic value. Placental and neonatal discordant growth may allude to a vascular anomaly predisposing fetuses to developing CHD. Further studies are needed to explore fetal nutrient delivery and utilization efficiency.
UNASSIGNED: This study aimed to characterize the relationship between neonatal birthweight (BW), head circumference, placental weight (PW), and placental pathology in pregnancies affected by CHD. PW:BW provides a surrogate to assess placental efficiency, or nutrient exchange and delivery by the placenta, across CHD phenotypes.
UNASSIGNED: Retrospective cohort of 139 live-born singletons with postnatally confirmed CHD with placental pathology. Placental examination, infant BW, head circumference, and CHD categories (septal defects, right-sided defects, left-sided defects, conotruncal anomalies, and others) were included. Chi-square, Fisher\'s exact, or Kruskall-Wallis tests and multinomial logistic regressions, as appropriate.
UNASSIGNED: Median birthweight and head circumference percentile was 33 and 35, respectively. Placental pathology was documented in 37% of cases. PW to BW ratios were <10th percentile for 78% and <3rd percentile for 54% of the cohort, with no difference between CHD categories (P = 0.39 and P = 0.56, respectively).
UNASSIGNED: Infants with CHD have preserved BW and head circumferences in the setting of small placentas and increased prevalence of placental pathology, suggesting placental efficiency. Detection of abnormal placental growth could add prenatal diagnostic value. Placental and neonatal discordant growth may allude to a vascular anomaly predisposing fetuses to developing CHD. Further studies are needed to explore fetal nutrient delivery and utilization efficiency.
摘要：
先天性心脏病（CHD）影响每1,000个活产中就有8个，对出生后有重大影响，包括生长障碍，神经发育迟缓,和死亡率。胎盘与胎儿心脏同时发育。受CHD影响的妊娠中胎盘病理和不一致生长的高率突出了胎儿-胎盘-心脏轴的重要性。
■本研究旨在表征新生儿出生体重(BW)之间的关系，头围,胎盘重量（PW），和受冠心病影响的妊娠胎盘病理。PW：BW提供了评估胎盘效率的替代方法，或者胎盘的营养交换和分娩，跨CHD表型。
■回顾性队列研究了139例出生后确诊的CHD伴胎盘病理的单胎。胎盘检查,婴儿BW,头围,和冠心病类别(间隔缺损，右侧缺陷,左侧缺陷，conotruncal异常,和其他)被包括在内。卡方，费希尔的精确,或者Kruskall-Wallis检验和多项逻辑回归，视情况而定。
■出生体重中位数和头围百分位数分别为33和35。在37％的病例中记录了胎盘病理学。PW与BW之比<10百分位数（78%），<3百分位数（54%），CHD类别之间没有差异（分别为P=0.39和P=0.56）。
■CHD婴儿在小胎盘环境中保留了体重和头围，胎盘病理患病率增加，提示胎盘效率。检测胎盘异常生长可以增加产前诊断价值。胎盘和新生儿不一致的生长可能暗示血管异常使胎儿容易发展为CHD。需要进一步的研究来探索胎儿营养素的分娩和利用效率。
■本研究旨在表征新生儿出生体重(BW)之间的关系，头围,胎盘重量（PW），和受冠心病影响的妊娠胎盘病理。PW：BW提供了评估胎盘效率的替代方法，或者胎盘的营养交换和分娩，跨CHD表型。
■回顾性队列研究了139例出生后确诊的CHD伴胎盘病理的单胎。胎盘检查,婴儿BW,头围,和冠心病类别(间隔缺损，右侧缺陷,左侧缺陷，conotruncal异常,和其他)被包括在内。卡方，费希尔的精确,或者Kruskall-Wallis检验和多项逻辑回归，视情况而定。
■出生体重中位数和头围百分位数分别为33和35。在37％的病例中记录了胎盘病理学。PW与BW之比<10百分位数（78%），<3百分位数（54%），CHD类别之间没有差异（分别为P=0.39和P=0.56）。
■CHD婴儿在小胎盘环境中保留了体重和头围，胎盘病理患病率增加，提示胎盘效率。检测胎盘异常生长可以增加产前诊断价值。胎盘和新生儿不一致的生长可能暗示血管异常使胎儿容易发展为CHD。需要进一步的研究来探索胎儿营养素的分娩和利用效率。
