PDF(Pubmed)
Abstract：
Due to the advanced studies on stem cells in developmental biology, the roles of stem cells in the body and their phenotypes in related diseases have not been covered clearly. Meanwhile, with the intensive research on the mechanisms of stem cells in regulating various diseases, stem cell therapy is increasingly being attention because of its effectiveness and safety. As one of the most widely used stem cell in stem cell therapies, hematopoietic stem cell transplantation shows huge advantage in treatment of leukemia and other blood-malignant diseases. Besides, due to the effect of anti-inflammatory and immunomodulatory, mesenchymal stem cells could be a potential therapeutic strategy for variety infectious diseases. In this review, we summarized the effects of Staphylococcus aureus (S. aureus) and its components on different types of adult stem cells and their downstream signaling pathways. Also, we reviewed the roles of different kinds of stem cells in various disease models caused by S. aureus, providing new insights for applying stem cell therapy to treat infectious diseases.
摘要：
由于干细胞在发育生物学中的先进研究，干细胞在体内的作用及其在相关疾病中的表型尚未明确涵盖。同时,随着对干细胞调节各种疾病机制的深入研究，干细胞治疗因其有效性和安全性日益受到重视。作为干细胞治疗中应用最广泛的干细胞之一,造血干细胞移植在白血病和其他血液恶性疾病的治疗中显示出巨大的优势。此外,由于抗炎和免疫调节的作用，间充质干细胞可能成为多种感染性疾病的潜在治疗策略。在这次审查中,我们总结了金黄色葡萄球菌(S.金黄色葡萄球菌）及其成分对不同类型成体干细胞及其下游信号通路的影响。此外，我们综述了不同种类的干细胞在金黄色葡萄球菌引起的各种疾病模型中的作用,为应用干细胞疗法治疗感染性疾病提供新的见解。
