PDF(Pubmed)
Abstract：
BACKGROUND: Although it is thought that prostatitis or benign prostatic hyperplasia (BPH) is related to prostate cancer (PCa), the underlying causal effects of these diseases are unclear.
METHODS: We assessed the causal relationship between prostatitis or BPH and PCa using a two-sample Mendelian randomization (MR) approach. The data utilized in this study were sourced from genome-wide association study. The association of genetic variants from cohorts of prostatitis or BPH and PCa patients was determined using inverse-variance weighted and MR Egger regression techniques. The direction of chance was determined using independent genetic variants with genome-wide significance (P < 5 × 10-6). The accuracy of the results was confirmed using sensitivity analyses.
RESULTS: MR analysis showed that BPH had a significant causal effect on PCa (Odds Ratio = 1.209, 95% Confidence Interval: 0.098-0.281, P = 5.079 × 10- 5) while prostatitis had no significant causal effect on PCa (P > 0.05). Additionally, the pleiotropic test and leave-one-out analysis showed the two-sample MR analyses were valid and reliable.
CONCLUSIONS: This MR study supports that BPH has a positive causal effect on PCa, while genetically predicted prostatitis has no causal effect on PCa. Nonetheless, further studies should explore the underlying biochemical mechanism and potential therapeutic targets for the prevention of these diseases.
METHODS: We assessed the causal relationship between prostatitis or BPH and PCa using a two-sample Mendelian randomization (MR) approach. The data utilized in this study were sourced from genome-wide association study. The association of genetic variants from cohorts of prostatitis or BPH and PCa patients was determined using inverse-variance weighted and MR Egger regression techniques. The direction of chance was determined using independent genetic variants with genome-wide significance (P < 5 × 10-6). The accuracy of the results was confirmed using sensitivity analyses.
RESULTS: MR analysis showed that BPH had a significant causal effect on PCa (Odds Ratio = 1.209, 95% Confidence Interval: 0.098-0.281, P = 5.079 × 10- 5) while prostatitis had no significant causal effect on PCa (P > 0.05). Additionally, the pleiotropic test and leave-one-out analysis showed the two-sample MR analyses were valid and reliable.
CONCLUSIONS: This MR study supports that BPH has a positive causal effect on PCa, while genetically predicted prostatitis has no causal effect on PCa. Nonetheless, further studies should explore the underlying biochemical mechanism and potential therapeutic targets for the prevention of these diseases.
摘要：
背景：尽管认为前列腺炎或良性前列腺增生（BPH）与前列腺癌（PCa）有关，这些疾病的潜在因果效应尚不清楚.
方法：我们使用双样本孟德尔随机化（MR）方法评估了前列腺炎或BPH与PCa之间的因果关系。本研究中使用的数据来自全基因组关联研究。使用逆方差加权和MREgger回归技术确定前列腺炎或BPH和PCa患者队列的遗传变异的关联。使用具有全基因组显著性(P<5×10-6)的独立遗传变异确定机会方向。使用敏感性分析证实了结果的准确性。
结果：MR分析显示BPH对PCa有显著的因果效应（几率=1.209，95%置信区间：0.098～0.281，P=5.079×10-5），而前列腺炎对PCa无显著因果效应（P>0.05）。此外,多效性试验和留一分析显示,双样本MR分析有效可靠.
结论：这项MR研究支持BPH对PCa有积极的因果关系，而遗传预测的前列腺炎对PCa没有因果关系。尽管如此，进一步的研究应该探索预防这些疾病的潜在生化机制和潜在的治疗靶点。
方法：我们使用双样本孟德尔随机化（MR）方法评估了前列腺炎或BPH与PCa之间的因果关系。本研究中使用的数据来自全基因组关联研究。使用逆方差加权和MREgger回归技术确定前列腺炎或BPH和PCa患者队列的遗传变异的关联。使用具有全基因组显著性(P<5×10-6)的独立遗传变异确定机会方向。使用敏感性分析证实了结果的准确性。
结果：MR分析显示BPH对PCa有显著的因果效应（几率=1.209，95%置信区间：0.098～0.281，P=5.079×10-5），而前列腺炎对PCa无显著因果效应（P>0.05）。此外,多效性试验和留一分析显示,双样本MR分析有效可靠.
结论：这项MR研究支持BPH对PCa有积极的因果关系，而遗传预测的前列腺炎对PCa没有因果关系。尽管如此，进一步的研究应该探索预防这些疾病的潜在生化机制和潜在的治疗靶点。
