PDF(Pubmed)
Abstract：
Developing superporous hemostatic sponges with simultaneously enhanced permeability and mechanical properties remains challenging but highly desirable to achieve rapid hemostasis for non-compressible hemorrhage. Typical approaches to improve the permeability of hemostatic sponges by increasing porosity sacrifice mechanical properties and yield limited pore interconnectivity, thereby undermining the hemostatic efficacy and subsequent tissue regeneration. Herein, we propose a temperature-assisted secondary network compaction strategy following the phase separation-induced primary compaction to fabricate the superporous chitosan sponge with highly-interconnected porous structure, enhanced blood absorption rate and capacity, and fatigue resistance. The superporous chitosan sponge exhibits rapid shape recovery after absorbing blood and maintains sufficient pressure on wounds to build a robust physical barrier to greatly improve hemostatic efficiency. Furthermore, the superporous chitosan sponge outperforms commercial gauze, gelatin sponges, and chitosan powder by enhancing hemostatic efficiency, cell infiltration, vascular regeneration, and in-situ tissue regeneration in non-compressible organ injury models, respectively. We believe the proposed secondary network compaction strategy provides a simple yet effective method to fabricate superporous hemostatic sponges for diverse clinical applications.
摘要：
开发具有同时增强的渗透性和机械性能的超多孔止血海绵仍然具有挑战性,但对于实现不可压缩的出血的快速止血是非常期望的。通过增加孔隙度来提高止血海绵的渗透性的典型方法牺牲机械性能并产生有限的孔互连性。从而破坏止血功效和随后的组织再生。在这里，我们提出了一种温度辅助的二次网络压实策略，在相分离诱导的初级压实后，制造具有高度互连多孔结构的超多孔壳聚糖海绵，提高血液吸收率和容量，和抗疲劳性。超多孔壳聚糖海绵在吸收血液后表现出快速的形状恢复，并在伤口上保持足够的压力，以建立坚固的物理屏障，从而大大提高止血效率。此外，超多孔壳聚糖海绵的性能优于商业纱布，明胶海绵，和壳聚糖粉末通过提高止血效率，细胞浸润,血管再生,和非可压缩器官损伤模型中的原位组织再生，分别。我们相信所提出的二次网络压缩策略提供了一种简单而有效的方法来制造用于多种临床应用的超多孔止血海绵。
