Abstract：
OBJECTIVE: To evaluate the clinical features of patients with Systemic Lupus Erythematosus (SLE) and explore the risk factors of disease activity and renal damage.
METHODS: A retrospective study involving 194 patients were performed. Patients were divided into lupus nephritis (LN) group (63.40%) and non-LN group (36.60%), different disease activity group, and different renal function group according to the clinical data. Multivariate logistic regression analysis showed that albumin (ALB), uric acid (UC), total cholesterol (TC), and anti-dsDNA antibodies were the influencing factors of LN in patients with SLE (P < 0.05); ALB, UC, and complement 3(C3) were the influencing factors of lupus disease activity (P < 0.05); UC, C3, and hemoglobin (HB) were the influencing factors of abnormal renal function in SLE patients.
RESULTS: The results of the ROC curve showed that ALB, UA, and TC had certain predictive value for combined LN in patients with SLE, and the predictive value of ALB was greater than that of TC (P < 0.05); ALB, UA, and C3 being predictors of the activity of patients with SLE; BUN, UA, and HB all had certain predictive value for the abnormal renal function in patients with LN. SLE patients have the high incidence of renal impairment.
CONCLUSIONS: The results of this study suggest that patients with SLE should regularly monitor the levels of ALB, UA, TC, C3, and HB, as well as pay attention to the intervention of hyperlipidemia and hyperuricemia in patients with SLE to better control disease progression.
METHODS: A retrospective study involving 194 patients were performed. Patients were divided into lupus nephritis (LN) group (63.40%) and non-LN group (36.60%), different disease activity group, and different renal function group according to the clinical data. Multivariate logistic regression analysis showed that albumin (ALB), uric acid (UC), total cholesterol (TC), and anti-dsDNA antibodies were the influencing factors of LN in patients with SLE (P < 0.05); ALB, UC, and complement 3(C3) were the influencing factors of lupus disease activity (P < 0.05); UC, C3, and hemoglobin (HB) were the influencing factors of abnormal renal function in SLE patients.
RESULTS: The results of the ROC curve showed that ALB, UA, and TC had certain predictive value for combined LN in patients with SLE, and the predictive value of ALB was greater than that of TC (P < 0.05); ALB, UA, and C3 being predictors of the activity of patients with SLE; BUN, UA, and HB all had certain predictive value for the abnormal renal function in patients with LN. SLE patients have the high incidence of renal impairment.
CONCLUSIONS: The results of this study suggest that patients with SLE should regularly monitor the levels of ALB, UA, TC, C3, and HB, as well as pay attention to the intervention of hyperlipidemia and hyperuricemia in patients with SLE to better control disease progression.
摘要：
目的：评价系统性红斑狼疮(SLE)患者的临床特点，探讨SLE患者病情活动性和肾损害的危险因素。
方法：对194例患者进行回顾性研究。将患者分为狼疮性肾炎(LN)组(63.40%)和非LN组(36.60%),不同的疾病活动组，根据临床资料不同肾功能组。多因素logistic回归分析显示白蛋白(ALB)、尿酸（UC），总胆固醇(TC),和抗dsDNA抗体是SLE患者LN的影响因素(P<0.05);ALB,UC,补体3(C3)是狼疮疾病活动度的影响因素(P<0.05);UC,C3、血红蛋白(HB)是SLE患者肾功能异常的影响因素。
结果：ROC曲线结果显示ALB,UA,TC对SLE合并LN有一定的预测价值,ALB的预测价值大于TC(P<0.05);ALB,UA,和C3是SLE患者活动的预测因子；BUN，UA,Hb和Hb均对LN患者肾功能异常有一定的预测价值。SLE患者肾损害发生率高。
结论：本研究结果表明，SLE患者应定期监测ALB水平，UA,TC,C3和HB，同时注意对SLE患者的高脂血症和高尿酸血症的干预,以更好地控制病情进展。
方法：对194例患者进行回顾性研究。将患者分为狼疮性肾炎(LN)组(63.40%)和非LN组(36.60%),不同的疾病活动组，根据临床资料不同肾功能组。多因素logistic回归分析显示白蛋白(ALB)、尿酸（UC），总胆固醇(TC),和抗dsDNA抗体是SLE患者LN的影响因素(P<0.05);ALB,UC,补体3(C3)是狼疮疾病活动度的影响因素(P<0.05);UC,C3、血红蛋白(HB)是SLE患者肾功能异常的影响因素。
结果：ROC曲线结果显示ALB,UA,TC对SLE合并LN有一定的预测价值,ALB的预测价值大于TC(P<0.05);ALB,UA,和C3是SLE患者活动的预测因子；BUN，UA,Hb和Hb均对LN患者肾功能异常有一定的预测价值。SLE患者肾损害发生率高。
结论：本研究结果表明，SLE患者应定期监测ALB水平，UA,TC,C3和HB，同时注意对SLE患者的高脂血症和高尿酸血症的干预,以更好地控制病情进展。
