PDF(Pubmed)
Abstract：
OBJECTIVE: Equol is metabolized by intestinal bacteria from soy isoflavones and is chemically similar to estrogen. Dietary habits, such as consumption of soy products, influence equol production. A relationship between glaucoma and estrogen has been identified; here, we investigated the relationship between equol production status and glaucoma in Japan.
METHODS: We recruited 68 normal-tension glaucoma (NTG) patients (male to female ratio 26:42, average age 63.0 ± 7.6 years) and 31 controls (male to female ratio 13:18, average age 66.0 ± 6.3 years) from our hospital. All women included were postmenopausal. Urinary equol concentration was quantified with the ELISA method. MD was calculated based on the Humphrey visual field. The association between MD and equol was analyzed with Spearman\'s rank correlation coefficient. The Mann-Whitney U test was used to compare the equol-producing (> 1 μM) and non-producing (< 1 μM) subjects. We also investigated the association between equol and glaucoma with a logistic regression analysis.
RESULTS: There was a significant association between equol and MD (r = 0.36, P < 0.01) in the NTG patients. Glaucoma, represented by MD, was significantly milder in the equol-producing subjects than the non-equol producing subjects (P = 0.03). A multivariate analysis revealed the independent contributions of equol, cpRNFLT, and IOP to MD (P = 0.03, P = 0.04, and P < 0.01, respectively).
CONCLUSIONS: Our results suggest that equol, acting through estrogen receptor-mediated neuroprotective effects, might be involved in suppressing the progression of NTG. This result also adds to evidence that glaucoma may be influenced by lifestyle.
METHODS: We recruited 68 normal-tension glaucoma (NTG) patients (male to female ratio 26:42, average age 63.0 ± 7.6 years) and 31 controls (male to female ratio 13:18, average age 66.0 ± 6.3 years) from our hospital. All women included were postmenopausal. Urinary equol concentration was quantified with the ELISA method. MD was calculated based on the Humphrey visual field. The association between MD and equol was analyzed with Spearman\'s rank correlation coefficient. The Mann-Whitney U test was used to compare the equol-producing (> 1 μM) and non-producing (< 1 μM) subjects. We also investigated the association between equol and glaucoma with a logistic regression analysis.
RESULTS: There was a significant association between equol and MD (r = 0.36, P < 0.01) in the NTG patients. Glaucoma, represented by MD, was significantly milder in the equol-producing subjects than the non-equol producing subjects (P = 0.03). A multivariate analysis revealed the independent contributions of equol, cpRNFLT, and IOP to MD (P = 0.03, P = 0.04, and P < 0.01, respectively).
CONCLUSIONS: Our results suggest that equol, acting through estrogen receptor-mediated neuroprotective effects, might be involved in suppressing the progression of NTG. This result also adds to evidence that glaucoma may be influenced by lifestyle.
摘要：
目的：雌马酚被肠道细菌从大豆异黄酮中代谢出来，在化学上与雌激素相似。饮食习惯,比如豆制品的消费，影响雌马酚的生产。青光眼和雌激素之间的关系已经被确定;这里,我们调查了日本雌马酚产生状况与青光眼之间的关系.
方法：我们从我院招募了68名正常眼压性青光眼（NTG）患者（男女比例26：42，平均年龄63.0±7.6岁）和31名对照（男女比例13：18，平均年龄66.0±6.3岁）。纳入的所有女性均为绝经后。用ELISA方法定量尿雌马酚浓度。MD是根据汉弗莱视野计算的。采用Spearman秩相关系数分析MD与雌马酚的相关性。Mann-WhitneyU检验用于比较雌马酚产生(>1μM)和不产生(<1μM)的受试者。我们还通过逻辑回归分析研究了雌马酚与青光眼之间的关系。
结果：在NTG患者中，雌马酚与MD之间存在显着相关性（r=0.36，P<0.01）。青光眼,以MD为代表，与不产生雌马酚的受试者相比，产生雌马酚的受试者明显更温和（P=0.03）。多变量分析揭示了雌马酚的独立贡献，cpRNFLT,和IOP到MD（分别为P=0.03，P=0.04和P<0.01）。
结论：我们的结果表明雌马酚，通过雌激素受体介导的神经保护作用，可能参与抑制NTG的进展。这一结果也增加了青光眼可能受生活方式影响的证据。
方法：我们从我院招募了68名正常眼压性青光眼（NTG）患者（男女比例26：42，平均年龄63.0±7.6岁）和31名对照（男女比例13：18，平均年龄66.0±6.3岁）。纳入的所有女性均为绝经后。用ELISA方法定量尿雌马酚浓度。MD是根据汉弗莱视野计算的。采用Spearman秩相关系数分析MD与雌马酚的相关性。Mann-WhitneyU检验用于比较雌马酚产生(>1μM)和不产生(<1μM)的受试者。我们还通过逻辑回归分析研究了雌马酚与青光眼之间的关系。
结果：在NTG患者中，雌马酚与MD之间存在显着相关性（r=0.36，P<0.01）。青光眼,以MD为代表，与不产生雌马酚的受试者相比，产生雌马酚的受试者明显更温和（P=0.03）。多变量分析揭示了雌马酚的独立贡献，cpRNFLT,和IOP到MD（分别为P=0.03，P=0.04和P<0.01）。
结论：我们的结果表明雌马酚，通过雌激素受体介导的神经保护作用，可能参与抑制NTG的进展。这一结果也增加了青光眼可能受生活方式影响的证据。
