Abstract：
OBJECTIVE: To evaluate the relationship between AMH and ovarian response to controlled ovarian hyperstimulation in women with PCOM and PCOS.
METHODS: A retrospective study was conducted on 559 patients who underwent the IVF-ET cycle between January 2018 and December 2022 at Gangnam Cha Hospital. Patients were divided into 3 groups matched for age and BMI: the PCOS group (n = 54), based on the new 2023 PCOS guideline; the PCOM group (n = 53); and the control group (n = 452) with normal ovaries. Serum AMH levels were converted to multiples of the median (MoM) for each corresponding age. The ovarian sensitivity index (OSI) was calculated as the number of retrieved oocytes divided by the total dose of recombinant FSH administered (per 1000 IU).
RESULTS: There were significant differences in AMH-MoM value among women with PCOS [2.7 ± 1.3 (95% CI 2.3-3.0)], those with PCOM [2.0 ± 1.0 (95% CI 1.7-2.3)], and controls [0.8 ± 0.7 (95% CI 0.8-0.9)] (p < 0.001). The abortion rates in the normoovulatory, PCOM, and PCOS groups were 18.2%, 21.1%, and 25.0%, respectively. OSI and live birth rate were positively correlated with the AMH-MoM value in normoovulatory women (r = 0.389, p < 0.05, r = 0.122, p < 0.05), while no such correlation was observed in women with PCOM and PCOS.
CONCLUSIONS: Ovarian response and live birth rate are possibly correlated with the AMH-MoM value in normoovulatory women, but not in women with PCOM and PCOS.
METHODS: A retrospective study was conducted on 559 patients who underwent the IVF-ET cycle between January 2018 and December 2022 at Gangnam Cha Hospital. Patients were divided into 3 groups matched for age and BMI: the PCOS group (n = 54), based on the new 2023 PCOS guideline; the PCOM group (n = 53); and the control group (n = 452) with normal ovaries. Serum AMH levels were converted to multiples of the median (MoM) for each corresponding age. The ovarian sensitivity index (OSI) was calculated as the number of retrieved oocytes divided by the total dose of recombinant FSH administered (per 1000 IU).
RESULTS: There were significant differences in AMH-MoM value among women with PCOS [2.7 ± 1.3 (95% CI 2.3-3.0)], those with PCOM [2.0 ± 1.0 (95% CI 1.7-2.3)], and controls [0.8 ± 0.7 (95% CI 0.8-0.9)] (p < 0.001). The abortion rates in the normoovulatory, PCOM, and PCOS groups were 18.2%, 21.1%, and 25.0%, respectively. OSI and live birth rate were positively correlated with the AMH-MoM value in normoovulatory women (r = 0.389, p < 0.05, r = 0.122, p < 0.05), while no such correlation was observed in women with PCOM and PCOS.
CONCLUSIONS: Ovarian response and live birth rate are possibly correlated with the AMH-MoM value in normoovulatory women, but not in women with PCOM and PCOS.
摘要：
目的：评估PCOM和PCOS患者对控制性超促排卵的卵巢反应与AMH的关系。
方法：对2018年1月至2022年12月在江南医院接受IVF-ET周期的559例患者进行了回顾性研究。患者分为年龄和BMI匹配的3组：PCOS组（n=54），根据新的2023PCOS指南;PCOM组（n=53）和卵巢正常的对照组（n=452）。将血清AMH水平转换为每个相应年龄的中位数（MoM）的倍数。卵巢敏感性指数（OSI）计算为回收的卵母细胞数除以所施用的重组FSH的总剂量（每1000IU）。
结果：PCOS患者的AMH-MoM值存在显着差异[2.7±1.3（95％CI2.3-3.0）]，PCOM[2.0±1.0（95%CI1.7-2.3）]，和对照组[0.8±0.7(95%CI0.8-0.9)](p<0.001)。正常排卵的流产率，PCOM,PCOS组为18.2%,21.1%,和25.0%，分别。OSI和活产率与正常排卵妇女AMH-MoM值呈正相关(r=0.389,p<0.05,r=0.122,p<0.05),而在患有PCOM和PCOS的女性中未观察到这种相关性。
结论：卵巢反应和活产率可能与正常排卵妇女的AMH-MoM值相关，但在PCOM和PCOS的女性中却没有。
方法：对2018年1月至2022年12月在江南医院接受IVF-ET周期的559例患者进行了回顾性研究。患者分为年龄和BMI匹配的3组：PCOS组（n=54），根据新的2023PCOS指南;PCOM组（n=53）和卵巢正常的对照组（n=452）。将血清AMH水平转换为每个相应年龄的中位数（MoM）的倍数。卵巢敏感性指数（OSI）计算为回收的卵母细胞数除以所施用的重组FSH的总剂量（每1000IU）。
结果：PCOS患者的AMH-MoM值存在显着差异[2.7±1.3（95％CI2.3-3.0）]，PCOM[2.0±1.0（95%CI1.7-2.3）]，和对照组[0.8±0.7(95%CI0.8-0.9)](p<0.001)。正常排卵的流产率，PCOM,PCOS组为18.2%,21.1%,和25.0%，分别。OSI和活产率与正常排卵妇女AMH-MoM值呈正相关(r=0.389,p<0.05,r=0.122,p<0.05),而在患有PCOM和PCOS的女性中未观察到这种相关性。
结论：卵巢反应和活产率可能与正常排卵妇女的AMH-MoM值相关，但在PCOM和PCOS的女性中却没有。
