Abstract：
Atherosclerosis, a chronic inflammatory condition, remains a leading cause of death globally, necessitating innovative approaches to target pro-atherogenic pathways. Recent advancements in the field of immunometabolism have highlighted the crucial interplay between metabolic pathways and immune cell function in atherogenic milieus. Macrophages and T cells undergo dynamic metabolic reprogramming to meet the demands of activation and differentiation, influencing plaque progression. Furthermore, metabolic intermediates intricately regulate immune cell responses and atherosclerosis development. Understanding the metabolic control of immune responses in atherosclerosis, known as athero-immunometabolism, offers new avenues for preventive and therapeutic interventions. This review elucidates the emerging intricate interplay between metabolism and immunity in atherosclerosis, underscoring the significance of metabolic enzymes and metabolites as key regulators of disease pathogenesis and therapeutic targets.
摘要：
动脉粥样硬化,慢性炎症,仍然是全球死亡的主要原因，需要创新的方法来靶向促动脉粥样硬化途径。免疫代谢领域的最新进展强调了动脉粥样硬化中代谢途径与免疫细胞功能之间的关键相互作用。巨噬细胞和T细胞进行动态代谢重编程，以满足活化和分化的需求，影响斑块进展。此外，代谢中间体复杂地调节免疫细胞反应和动脉粥样硬化的发展。了解动脉粥样硬化中免疫反应的代谢控制，被称为动脉粥样硬化免疫代谢，为预防和治疗干预提供了新的途径。这篇综述阐明了动脉粥样硬化中代谢和免疫之间新兴的复杂相互作用。强调代谢酶和代谢物作为疾病发病机制和治疗靶点的关键调节因子的重要性。
