Abstract：
Morphogenesis is a physical process that sculpts the final functional forms of tissues and organs. Remarkably, the lungs of terrestrial vertebrates vary dramatically in form across species, despite providing the same function of transporting oxygen and carbon dioxide. These divergent forms arise from distinct physical processes through which the epithelium of the embryonic lung responds to the mechanical properties of its surrounding mesenchymal microenvironment. Here we compare the physical processes that guide folding of the lung epithelium in mammals, birds, and reptiles, and suggest a conceptual framework that reconciles how conserved molecular signaling generates divergent mechanical forces across these species.
摘要：
形态发生是雕刻组织和器官的最终功能形式的物理过程。值得注意的是,陆生脊椎动物的肺在不同物种之间的形态差异很大，尽管提供相同的传输氧气和二氧化碳的功能。这些不同的形式源于不同的物理过程，通过这些过程，胚胎肺的上皮对其周围的间充质微环境的机械特性作出反应。在这里，我们比较了指导哺乳动物肺上皮折叠的物理过程，鸟,和爬行动物,并提出了一个概念框架，以协调保守的分子信号如何在这些物种中产生不同的机械力。
