Abstract：
The gastrointestinal tract exhibits coordinated muscle motility in response to food digestion, which is regulated by the central nervous system through autonomic control. The insular cortex is one of the brain regions that may regulate the muscle motility. In this study, we examined whether, and how, the insular cortex, especially the posterior part, regulates gastrointestinal motility by recording jejunal myoelectrical signals in response to feeding in freely moving male rats. Feeding was found to induce increases in jejunal myoelectrical signal amplitudes. This increase in the jejunal myoelectrical signals was abolished by vagotomy and pharmacological inhibition of the posterior insular cortex. Additionally, feeding induced a decrease and increase in sympathetic and parasympathetic nervous activities, respectively, both of which were eliminated by posterior insular cortical inhibition. These results suggest that the posterior insular cortex regulates jejunal motility in response to feeding by modulating autonomic tone.
摘要：
胃肠道表现出协调的肌肉运动，以响应食物消化，由中枢神经系统通过自主神经控制来调节。岛叶皮层是可以调节肌肉运动的大脑区域之一。在这项研究中,我们检查了是否，以及如何，岛状皮层,尤其是后部，在自由移动的雄性大鼠中，通过记录空肠肌电信号来调节胃肠运动。发现喂食会引起空肠肌电信号振幅的增加。空肠肌电信号的这种增加被迷走神经切断术和后岛叶皮层的药理抑制所消除。此外,摄食引起交感神经和副交感神经活动的减少和增加，分别,两者都被后岛叶皮质抑制消除。这些结果表明，后岛叶皮层通过调节自主神经张力来调节空肠运动，以响应进食。
