Abstract：
Parkinson\'s disease (PD) is estimated to impact up to 1 % of the global population aged 60 years and older. Among the non-motor manifestations of idiopathic PD, radicular neuropathic pain emerges as a noteworthy concern due to its potential for debility in affected individuals. In, this systematic review and meta-analysis we aimed to evaluate the prevalence of radicular neuropathic pain and thus provide evidence of how this painful symptom affects the lives of patients with idiopathic PD. We registered the research protocol for this study in PROSPERO (CRD42022327220). We searched the Embase, Scopus, and PubMed platforms for studies on PD and neuropathic pain until April 2023. The search yielded 36 articles considered to have a low risk of bias. The prevalence of radicular neuropathic pain in patients with PD was 12.7 %, without a difference when we consider the duration of diagnosis (cut-off < 7 years) or levodopa dosage (cut-off <600 mg/dL). Moreover, there was no variation in the prevalence of radicular neuropathic pain regarding a Hoehn and Yahr stage cut-off of <2.5 or >2.5. Of note, a limited number of patients received pain treatment (21.5 %). We also found that the source of publication bias is the use of the Ford criteria (FC), suggesting that this type of diagnostic criteria may contribute to an underdiagnosis of radicular neuropathic pain in patients with PD. This study underlines the necessity for a more discerning and comprehensive approach to the diagnosis and management of radicular neuropathic pain in patients with idiopathic PD.
摘要：
据估计，帕金森病（PD）影响全球60岁及以上人口的1%。在特发性PD的非运动表现中，神经根神经性疼痛由于其在受影响的个体中的虚弱潜力而成为值得注意的问题。In,本系统综述和荟萃分析旨在评估神经根神经性疼痛的患病率,从而提供这种疼痛症状如何影响特发性PD患者生活的证据.我们在PROSPERO（CRD42022327220）中注册了本研究的研究方案。我们搜查了Embase,Scopus,和PubMed平台，用于研究PD和神经性疼痛，直到2023年4月。搜索产生了36篇被认为具有低偏见风险的文章。PD患者的神经根性疼痛患病率为12.7%,当我们考虑诊断持续时间（截止<7年）或左旋多巴剂量（截止<600mg/dL）时，没有差异。此外，在Hoehn和Yahr分期截止值<2.5或>2.5时,根性神经性疼痛的患病率没有变化.值得注意的是，接受疼痛治疗的患者数量有限(21.5%).我们还发现，出版偏见的来源是使用福特标准(FC)，提示这种类型的诊断标准可能导致PD患者神经根性疼痛的诊断不足.这项研究强调了对特发性PD患者的神经根神经性疼痛的诊断和管理采取更清晰和全面的方法的必要性。
