口服 Th17 拮抗剂小蛋白的原理的临床前证明。
关键词: IL-17 IL-23R Th17 autoinflammation computational protein design inflammatory bowel disease oral biologics protein engineering
Mesh : Animals Administration, Oral Mice Humans Rats Colitis / drug therapy Interleukin-17 / metabolism antagonists & inhibitors Th17 Cells / immunology Receptors, Interleukin / metabolism antagonists & inhibitors Mice, Inbred C57BL Male Interleukin-23 / metabolism antagonists & inhibitors Tissue Distribution Female Rats, Sprague-Dawley
来 源:
DOI:10.1016/j.cell.2024.05.052
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