Abstract：
BACKGROUND: The efficacy of medium-chain triglycerides (MCTs) for weight management and mitigating metabolic disorders among individuals with overweight and obesity remains a topic of ongoing discussion. Notably, there is a gap in the distinction between pure MCTs and medium-long-chain triglycerides (MLCTs).
METHODS: This meta-analysis investigates the efficacy of MCTs on weight loss and glucolipid metabolism in these populations, explicitly evaluating the differential effects of pure MCTs and MLCTs. We performed a random-effects meta-analysis on relevant studies examining weight loss and glucolipid parameters, incorporating a subgroup analysis conducted based on intervention types, pure MCTs versus MLCTs.
RESULTS: Our findings revealed diets enriched with MCTs are more effective in achieving weight reduction (WMD: -1.53%; 95% CI: -2.44, -0.63; p < 0.01), particularly those containing pure MCTs (WMD: -1.62%; 95% CI: -2.78, -0.46; p < 0.01), compared to long-chain fatty acids (LCTs) enriched diets. However, our subgroup analysis indicates that an MLCTs-enriched diet did not significantly reduce weight loss. Additionally, MCTs-enriched diets were associated with significant reductions in blood triglyceride levels and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) scores, compared to LCTs-enriched diets.
CONCLUSIONS: Hence, the authors recommend incorporating pure MCTs in dietary interventions for individuals with overweight and obesity, particularly those with comorbidities such as dyslipidemia and impaired glucose metabolism.
METHODS: This meta-analysis investigates the efficacy of MCTs on weight loss and glucolipid metabolism in these populations, explicitly evaluating the differential effects of pure MCTs and MLCTs. We performed a random-effects meta-analysis on relevant studies examining weight loss and glucolipid parameters, incorporating a subgroup analysis conducted based on intervention types, pure MCTs versus MLCTs.
RESULTS: Our findings revealed diets enriched with MCTs are more effective in achieving weight reduction (WMD: -1.53%; 95% CI: -2.44, -0.63; p < 0.01), particularly those containing pure MCTs (WMD: -1.62%; 95% CI: -2.78, -0.46; p < 0.01), compared to long-chain fatty acids (LCTs) enriched diets. However, our subgroup analysis indicates that an MLCTs-enriched diet did not significantly reduce weight loss. Additionally, MCTs-enriched diets were associated with significant reductions in blood triglyceride levels and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) scores, compared to LCTs-enriched diets.
CONCLUSIONS: Hence, the authors recommend incorporating pure MCTs in dietary interventions for individuals with overweight and obesity, particularly those with comorbidities such as dyslipidemia and impaired glucose metabolism.
摘要：
背景：中链甘油三酯（MCT）在超重和肥胖个体中控制体重和减轻代谢紊乱的功效仍然是一个持续讨论的话题。值得注意的是,纯MCT和中长链甘油三酯（MLCT）之间存在差异。
方法：本荟萃分析调查了这些人群中MCT对体重减轻和糖脂代谢的疗效。明确评估纯MCT和MLCT的差异效应。我们对研究体重减轻和糖脂参数的相关研究进行了随机效应荟萃分析，结合基于干预类型进行的亚组分析，纯MCT与MLCT。
结果：我们的发现表明，富含MCT的饮食在实现体重减轻方面更有效（WMD：-1.53％；95％CI：-2.44，-0.63；p<0.01），特别是含有纯MCT的那些(WMD:-1.62%;95%CI:-2.78,-0.46;p<0.01)，与富含长链脂肪酸（LCTs）的饮食相比。然而,我们的亚组分析表明,富含MLCTs的饮食并未显著降低体重减轻.此外,富含MCTs的饮食与血液甘油三酯水平和胰岛素抵抗稳态模型评估（HOMA-IR）评分的显着降低相关。与富含LCTs的饮食相比。
结论：因此，作者建议将纯MCT纳入超重和肥胖个体的饮食干预措施，尤其是那些有血脂异常和葡萄糖代谢受损等合并症的患者。
方法：本荟萃分析调查了这些人群中MCT对体重减轻和糖脂代谢的疗效。明确评估纯MCT和MLCT的差异效应。我们对研究体重减轻和糖脂参数的相关研究进行了随机效应荟萃分析，结合基于干预类型进行的亚组分析，纯MCT与MLCT。
结果：我们的发现表明，富含MCT的饮食在实现体重减轻方面更有效（WMD：-1.53％；95％CI：-2.44，-0.63；p<0.01），特别是含有纯MCT的那些(WMD:-1.62%;95%CI:-2.78,-0.46;p<0.01)，与富含长链脂肪酸（LCTs）的饮食相比。然而,我们的亚组分析表明,富含MLCTs的饮食并未显著降低体重减轻.此外,富含MCTs的饮食与血液甘油三酯水平和胰岛素抵抗稳态模型评估（HOMA-IR）评分的显着降低相关。与富含LCTs的饮食相比。
结论：因此，作者建议将纯MCT纳入超重和肥胖个体的饮食干预措施，尤其是那些有血脂异常和葡萄糖代谢受损等合并症的患者。
